Latent TB Infection (LTBI) - Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground
Por:
Rao, M, Ippolito, G, Mfinanga, S, Ntoumi, F, Yeboah-Manu, D, Vilaplana, C, Zumla, A and Maeurer, M
Publicada:
1 mar 2019
Ahead of Print:
26 feb 2019
Resumen:
Latent tuberculosis infection (LTBI) is established in over 90% of persons infected with Mycobacterium tuberculosis (Mtb), from whom new active TB cases will arise. Understanding the spatio-temporal dynamics of host immune responses in LTBI granulomas is essential to designing effective post-exposure therapies that inhibit progression to TB. Information arising from cancer studies and other modalities where local chronic inflammation leads to immunopathology - can help provide insights into the biological pathways at play in LTBI granulomas. Translational studies using patient material as well as LTBI+ donor-derived tissue samples are instrumental in understanding the various components of granuloma dynamics, immunological landscapes therein and how this could help to identify therapeutic targets. Deep sequencing technologies may aid to decipher the genetic changes in lung granuloma and blood samples from LTBI+ individuals associated with progression to active TB disease. This may lead to advancement of development of targeted Host-Directed Therapies (HDTs) and their evaluation as adjunct TB therapies for improving treatment outcomes for LTBI and pulmonary TB. (c) 2019 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Rao, M:
Champalimaud Ctr Unknown, Ave Brasilia, P-1400038 Lisbon, Portugal
Ippolito, G:
Lazzaro Spallanzani, Natl Inst Infect Dis, Rome, Italy
Mfinanga, S:
Natl Inst Med Res Muhimbili, Dar Es Salaam, Tanzania
Ntoumi, F:
Univ Marten NGouabi, Brazzaville, Rep Congo
FCRM, Brazzaville, Rep Congo
Univ Tubingen, Inst Trop Med, Tubingen, Germany
Yeboah-Manu, D:
Noguchi Mem Inst Med Res, Dept Bacteriol, Accra, Ghana
:
UAB, Expt TB Unit UTE, Fdn Inst Germans Trias & Pujol IGTP, Badalona, Catalonia, Spain
Zumla, A:
UCL, Div Infect & Immun, London, England
UCL Hosp NHS Fdn Trust, Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
Maeurer, M:
Champalimaud Ctr Unknown, Ave Brasilia, P-1400038 Lisbon, Portugal
Krankenhaus NW Frankfurt, Dept Haematol & Oncol, Frankfurt, Germany
Green Published, Green Submitted, gold
|