Impact of response to treatment in health-related quality of life patient-reported outcomes in elderly patients with relapsed multiple myeloma
Por:
Oriol, A, Ibarra, G, Abella, E, Motllo, C, Cibeira, MT, Garcia, A, Escoda, L, Granell, M, Ben-Azaiz, R, Cervera, M, Cabezudo, E, Fernandez, C and Rosinol, L
Publicada:
2 ene 2021
Ahead of Print:
1 sep 2020
Resumen:
Multiple myeloma (MM) is a recurrent malignancy with a high impact on quality of life. Improved survival relies on the combination of drugs and extended duration of therapy, raising concerns on its toxicity burden in elderly patients. Health-related quality of life measurements attent to capture health aspects relevant to patients other than efficacy. This prospective study aimed to understand the relationship between MM-related symptomatology and other quality of life dimensions using the EORTC QLQ-MY20 questionnaire in individuals with relapsed or refractory MM. Irrespective of treatment modality, over 50% of patients who responded to treatment had significant omprovements of reported scores in all domains. Conversely, disease progression was associated with score deterioration not only in the MM-related symptoms domain but also in all other domains. HRQoL adds valuable information to the established efficacy endpoints but an adequate interpretation of HRQoL outcomes in randomized trials should require stratification according to response.
Filiaciones:
:
Hosp Badalona Germans Trias & Pujol, Inst Josep Carreras, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain
:
Hosp Badalona Germans Trias & Pujol, Inst Josep Carreras, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain
Abella, E:
Hosp del Mar, Hematol Serv, Barcelona, Spain
Motllo, C:
Hosp San Juan Dios, Hematol Dept, Manresa, Spain
Cibeira, MT:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Garcia, A:
Hosp Arnau Vilanova, Lleida, Spain
Escoda, L:
Hosp Univ Tarragona Joan XXIII ICO Tarragona, Hematol Dept, Tarragona, Spain
Granell, M:
Hosp Santa Creu & Sant Pau, Hematol Serv, Barcelona, Spain
Ben-Azaiz, R:
Hosp del Mar, Hematol Serv, Barcelona, Spain
Cervera, M:
Hosp Univ Tarragona Joan XXIII ICO Tarragona, Hematol Dept, Tarragona, Spain
Cabezudo, E:
Hosp San Juan Dios, Hematol Dept, Manresa, Spain
Fernandez, C:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Rosinol, L:
Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
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