Complement as the enabler of carfilzomib-induced thrombotic microangiopathy
Por:
Blasco, M, Martinez-Roca, A, Rodriguez-Lobato, LG, Garcia-Herrera, A, Rosinol, L, Castro, P, Fernandez, S, Quintana, LF, Cibeira, MT, Blade, J, de Larrea, CF, Tovar, N, Jimenez, R, Poch, E, Guillen, E, Campistol, JM, Carreras, E, Diaz-Ricart, M and Palomo, M
Publicada:
1 abr 2021
Ahead of Print:
1 may 2020
Resumen:
Carfilzomib has been associated with the development of thrombotic microangiopathy (TMA) in relapsed/refractory multiple myeloma patients, a severe disease with no currently available aetiological treatment. We evaluated the potential role of terminal complement pathway in four patients with carfilzomib-induced TMA. Membrane attack complex (C5b-9) deposition on endothelial cells in culture exposed to plasma from patients during the acute phase of the disease suggests complement overactivation as a mechanism of potential endothelial damage in three out of four patients. If confirmed in larger cohorts, C5b-9 evaluation will allow early identification of patients who could benefit from complement blockade and treatment monitoring.
Filiaciones:
Blasco, M:
Univ Barcelona, Hosp Clin, Nephrol & Kidney Transplantat Dept, Ctr Referencia Enfermedad Glomerular Compleja Sis, Barcelona, Spain
Inst Biomed Res August Pi & Sunyer IDIPABS, Malalties Nefrourol & Trasplantament Renal, Barcelona, Spain
Martinez-Roca, A:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Rodriguez-Lobato, LG:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Garcia-Herrera, A:
Univ Barcelona, Hosp Clin, Dept Pathol, Barcelona, Spain
Rosinol, L:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Castro, P:
Univ Barcelona, Hosp Clin, Inst Biomed Res August Pi & Sunyer IDIPABS, Med Intens Care Unit, Barcelona, Spain
Fernandez, S:
Univ Barcelona, Hosp Clin, Inst Biomed Res August Pi & Sunyer IDIPABS, Med Intens Care Unit, Barcelona, Spain
Quintana, LF:
Univ Barcelona, Hosp Clin, Nephrol & Kidney Transplantat Dept, Ctr Referencia Enfermedad Glomerular Compleja Sis, Barcelona, Spain
Inst Biomed Res August Pi & Sunyer IDIPABS, Malalties Nefrourol & Trasplantament Renal, Barcelona, Spain
Cibeira, MT:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Blade, J:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
de Larrea, CF:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Tovar, N:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Jimenez, R:
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIPABS, Amyloidosis & Myeloma Unit,Dept Hematol, Barcelona, Spain
Poch, E:
Univ Barcelona, Hosp Clin, Nephrol & Kidney Transplantat Dept, Ctr Referencia Enfermedad Glomerular Compleja Sis, Barcelona, Spain
Inst Biomed Res August Pi & Sunyer IDIPABS, Malalties Nefrourol & Trasplantament Renal, Barcelona, Spain
Guillen, E:
Univ Barcelona, Hosp Clin, Nephrol & Kidney Transplantat Dept, Ctr Referencia Enfermedad Glomerular Compleja Sis, Barcelona, Spain
Campistol, JM:
Univ Barcelona, Hosp Clin, Nephrol & Kidney Transplantat Dept, Ctr Referencia Enfermedad Glomerular Compleja Sis, Barcelona, Spain
Inst Biomed Res August Pi & Sunyer IDIPABS, Malalties Nefrourol & Trasplantament Renal, Barcelona, Spain
:
Hosp Clin Barcelona, Josep Carreras Leukaemia Res Inst, Univ Barcelona Campus,C Villarroel 170, Barcelona 08036, Spain
Barcelona Endothelium Team, Barcelona, Spain
Diaz-Ricart, M:
Barcelona Endothelium Team, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIBAPS, Dept Hematopathol,Biomed Diag Ctr CDB, Barcelona, Spain
:
Hosp Clin Barcelona, Josep Carreras Leukaemia Res Inst, Univ Barcelona Campus,C Villarroel 170, Barcelona 08036, Spain
Barcelona Endothelium Team, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIBAPS, Dept Hematopathol,Biomed Diag Ctr CDB, Barcelona, Spain
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