Venous thromboembolism in young adults: Findings from the RIETE registry
Por:
Lacruz, B, Tiberio, G, Latorre, A, Villalba, JC, Bikdeli, B, Hirmerova, J, Lorenzo, A, Mellado, M, Canas, I, Monreal, M, Adarraga, MD, Agud, M, Agudo, P, Aibar, MA, Aibar, J, Amado, C, Arcelus, JI, Ballaz, A, Barba, R, Barron, M, Barron-Andres, B, Bascunana, J, Bolado, C, Blanco-Molina, A, Camon, AM, Canas, I, Carrasco, C, Castro, J, de Ancos, C, del Toro, J, Demelo, P, Diaz-Simon, R, Diaz-Peromingo, JA, Encabo, M, Falga, C, Farfan, AI, Fernandez-Capitan, C, Fernandez-Criado, MC, Fernandez-Ovalle, H, Fidalgo, MA, Font, C, Font, L, Furest, I, Garcia, MA, Garcia-Bragado, F, Garcia-Morillo, M, Garcia-Raso, A, Gavin, O, Gaya-Manso, I, Gayol, MC, Gil-Diaz, A, Gomez, V, Gomez-Cuervo, C, Gonzalez-Martinez, J, Grau, E, Gutierrez, J, Hernandez-Blasco, LM, Iglesias, M, Jara-Palomares, L, Jaras, MJ, Jimenez, D, Jou, I, Joya, MD, Lacruz, B, Lalueza, A, Lima, J, Llamas, P, Lobo, JL, Lopez-Jimenez, L, Lopez-Miguel, P, Lopez-Nunez, JJ, Lopez-Reyes, R, Lopez-Saez, JB, Lorente, MA, Lorenzo, A, Loring, M, Madridano, O, Maestre, A, Marchena, PJ, Martin, M, Martin-Fortea, MP, Martin-Guerra, JM, Martinez-Gonzalez, L, Melia, C, Mellado, M, Monreal, M, Montesa, C, Morales, MV, Nieto, MA, Nieto, JA, Nunez, MJ, Olivares, MC, Otalora, S, Otero, R, Ovejero, A, Pedrajas, JM, Pellejero, G, Perez-Ductor, C, Perez-Pinar, M, Perez-Rus, G, Penis, ML, Porras, JA, Redrado, J, Rivas, A, Rodriguez-Galan, I, Rodriguez-Hernandez, A, Rubio, CM, Ruiz-Artacho, P, Ruiz-Ruiz, J, Ruiz-Sada, P, Sahuquillo, JC, Sala-Sainz, MC, Salazar, V, Salgueiro, G, Samperiz, A, Sanchez-Camara, S, Sanchez-Munoz-Torrero, JF, Sancho, T, Soler, S, Surinach, JM, Tiberio, G, Tolosa, C, Torres, MI, Trujillo-Santos, J, Uresandi, F, Valle, R, Vidal, G, Villares, P, Gutierrez, P, Vazquez, FJ, Vilaseca, A, Vanassche, T, Vandenbriele, C, Verhamme, P, Yoo, HHB, Hirmerova, J, Maly, R, Salgado, E, Benzidia, I, Bertoletti, L, Bura-Riviere, A, Debourdeau, P, Farge-Bancel, D, Hij, A, Mahe, I, Merah, A, Moustafa, F, Schellong, S, Braester, A, Brenner, B, Ellis, M, Tzoran, I, Sharif-Kashani, B, Barillari, G, Bilora, F, Bortoluzzi, C, Brandolin, B, Ciammaichella, M, Dentali, F, Di Micco, P, Grandone, E, Maida, R, Mastroiacovo, D, Pace, F, Parisi, R, Pesavento, R, Prandoni, P, Quintavalla, R, Rocci, A, Siniscalchi, C, Sotgiu, P, Tufano, A, Visona, A, Hong, NV, Gibietis, V, Kigitovica, D, Skride, A, Bosevski, M, Bounameaux, H, Mazzolai, L, Bikdeli, B, Caprini, J, Bui, HM and Pham, KQ
Publicada:
1 may 2019
Ahead of Print:
11 mar 2019
Categoría:
Internal medicine
Resumen:
Background: Little is known on the clinical characteristics, risk factors and outcomes during anticoagulation in young patients with acute venous thromboembolism (VTE).
Methods: We used data from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry to assess the clinical characteristics, risk factors and outcomes during anticoagulation in VTE patients aged 10-24 years. Data were separately analyzed according to initial presentation and gender.
Results: Of 76,719 patients with VTE, 1571 (2.0%) were aged 10-24 years. Of these, 989 (63%) were women and 669 (43%) presented with pulmonary embolism (PE). Most women were using estrogens (680, 69%) or were pregnant (101, 10%), while 59% of men had unprovoked VTE. Women were more likely to present with PE (48% vs. 34%). The majority (87%) of PE patients had Sat O-2 levels >= 90% at baseline. The vast majority (97%) of PE patients were at low risk according to the PESI score, many (90%) at very low risk. During the course of anticoagulation (median, 192 days), 40 patients had VTE recurrences, 17 had major bleeding and 10 died (3 died of PE). Women had as many VTE recurrences as major bleeds (15 vs. 14 events), while men had many more VTE recurrences than major bleeding (25 vs. 3 events).
Conclusions: VTE is associated with low risk of short-term mortality in young adults. Noticeable gender differences exist in the risk factor profile and the risk of VTE recurrences and major bleeding in the course of anticoagulation.
Filiaciones:
Lacruz, B:
Complejo Hosp Navarra, Dept Internal Med, Navarra, Spain
Tiberio, G:
Complejo Hosp Navarra, Dept Internal Med, Navarra, Spain
Latorre, A:
Complexo Hosp Univ Ourense, Dept Internal Med, Orense, Spain
Villalba, JC:
Hosp Univ Germans Trios & Pujol Badalona, Intens Care Unit, Barcelona, Spain
Bikdeli, B:
Columbia Univ, New York Presbyterian Hosp, Med Ctr, Div Cardiol,Dept Med, New York, NY USA
Yale Sch Med, CORE, New Haven, CT USA
CRF, New York, NY USA
Hirmerova, J:
Univ Hosp Plzen, Dept Internal Med, Plzen, Czech Republic
Lorenzo, A:
Hosp Univ La Paz, Dept Internal Med, Madrid, Spain
Mellado, M:
Hosp de Mar, Dept Angiol & Vasc Surg, Barcelona, Spain
Canas, I:
Hosp Gen Granollers, Dept Internal Med, Barcelona, Spain
:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol Badalona, Dept Internal Med, Barcelona, Spain
Canas, I:
Hosp Gen Granollers, Dept Internal Med, Barcelona, Spain
Lacruz, B:
Complejo Hosp Navarra, Dept Internal Med, Navarra, Spain
Lorenzo, A:
Hosp Univ La Paz, Dept Internal Med, Madrid, Spain
Mellado, M:
Hosp de Mar, Dept Angiol & Vasc Surg, Barcelona, Spain
Monreal, M:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol Badalona, Dept Internal Med, Barcelona, Spain
Tiberio, G:
Complejo Hosp Navarra, Dept Internal Med, Navarra, Spain
Hirmerova, J:
Univ Hosp Plzen, Dept Internal Med, Plzen, Czech Republic
Bikdeli, B:
Columbia Univ, New York Presbyterian Hosp, Med Ctr, Div Cardiol,Dept Med, New York, NY USA
Yale Sch Med, CORE, New Haven, CT USA
CRF, New York, NY USA
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