The EuroSIDA study: 25 years of scientific achievements
Por:
Laut, K, Kirk, O, Rockstroh, J, Phillips, A, Ledergerber, B, Gatell, J, Gazzard, B, Horban, A, Karpov, I, Losso, M, Monforte, AD, Pedersen, C, Ristola, M, Reiss, P, Scherrer, AU, de Wit, S, Aho, I, Rasmussen, LD, Svedhem, V, Wandeler, G, Pradier, C, Chkhartishvili, N, Matulionyte, R, Oprea, C, Kowalska, JD, Begovac, J, Miro, JM, Guaraldi, G, Paredes, R, Raben, D, Podlekareva, D, Peters, L, Lundgren, JD and Mocroft, A
Publicada:
1 feb 2020
Ahead of Print:
1 oct 2019
Resumen:
The EuroSIDA study was initiated in 1994 and follows adult people living with HIV (PLHIV) in 100 collaborating clinics across 35 countries covering all European regions, Israel and Argentina. The study aims to study the long-term virological, immunological and clinical outcomes of PLHIV and to monitor temporal changes and regional differences in outcomes across Europe. Annually collected data include basic demographic characteristics, information on AIDS- and non-AIDS-related clinical events, and details about antiretroviral therapy (ART), hepatitis C treatment and other medications, in addition to a range of laboratory values. The summer 2016 data set held data from a total of 23 071 individuals contributing 174 481 person-years of follow-up, while EuroSIDA's unique plasma repository held over 160 000 samples. Over the past 25 years, close to 300 articles have been published in peer-reviewed journals (h-index 52), covering a range of scientific focus areas, including monitoring of clinical and virological outcomes, ART uptake, efficacy and adverse events, the influence of hepatitis virus coinfection, variation in the quality of HIV care and management across settings and regions, and biomarker research. Recognizing that there remain unresolved issues in the clinical care and management of PLHIV in Europe, EuroSIDA was one of the cohorts to found The International Cohort Consortium of Infectious Disease (RESPOND) cohort consortium on infectious diseases in 2017. In celebration of the EuroSIDA study's 25th anniversary, this article aims to summarize key scientific findings and outline current and future scientific focus areas.
Filiaciones:
Laut, K:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Kirk, O:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Rockstroh, J:
Univ Bonn, Bonn, Germany
Phillips, A:
UCL, Inst Global Hlth, Ctr Clin Res Epidemiol Modelling & Evaluat CREME, London, England
Ledergerber, B:
Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
Gatell, J:
Univ Barcelona, IDIBAPS, Hosp Clin, Barcelona, Spain
Gazzard, B:
Chelsea & Westminster Hosp, St Stephens Clin, London, England
Horban, A:
Med Univ Warsaw, Hosp Infect Dis Warsaw, Warsaw, Poland
Karpov, I:
Belarus State Med Univ, Dept Infect Dis, Minsk, BELARUS
Losso, M:
Latin Amer Coordinat Acad Clin Res, Buenos Aires, DF, Argentina
Monforte, AD:
Univ Milan, ASST St Paul & Charles, Clin Infect Dis, Dept Hlth Sci, Milan, Italy
Pedersen, C:
Odense Univ Hosp, Dept Infect Dis, Odense, Denmark
Ristola, M:
Helsinki Univ Hosp, Helsinki, Finland
Reiss, P:
Univ Amsterdam, Acad Med Ctr, Div Infect Dis, Amsterdam, Netherlands
Univ Amsterdam, Acad Med Ctr, Dept Global Hlth, Amsterdam, Netherlands
Stichting HIV Monitoring, Amsterdam, Netherlands
Scherrer, AU:
Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
de Wit, S:
CHU St Pierre, Brussels, Belgium
Aho, I:
Helsinki Univ Hosp, Helsinki, Finland
Rasmussen, LD:
Odense Univ Hosp, Dept Infect Dis, Odense, Denmark
Svedhem, V:
Karolinska Inst, Unit Infect Dis, Dept Med Huddinge, Stockholm, Sweden
Wandeler, G:
Univ Bern, Univ Hosp Bern, Dept Infect Dis, Bern, Switzerland
Pradier, C:
Archet Hosp, Nice, France
Chkhartishvili, N:
AIDS & Clin Immunol Res Ctr, Infect Dis, Tbilisi, Georgia
Matulionyte, R:
Vilnius Univ, Fac Med, Dept Infect Dis & Dermatovenerol, Vilnius, Lithuania
Vilnius Univ Hosp Santaros Klin, Ctr Infect Dis, Vilnius, Lithuania
Oprea, C:
Victor Babes Clin Hosp Infect & Trop Dis, Bucharest, Romania
Carol Davila Univ Med & Pharm, Bucharest, Romania
Kowalska, JD:
Med Univ Warsaw, Hosp Infect Dis Warsaw, Warsaw, Poland
Begovac, J:
Univ Hosp Infect Dis, Zagreb, Croatia
Miro, JM:
Univ Barcelona, IDIBAPS, Hosp Clin, Barcelona, Spain
Guaraldi, G:
Univ Modena & Reggio Emilia, Clin Infect Dis, Dept Med & Surg Sci Adults & Children, Modena, Italy
:
Germans Trias Hosp, Infect Dis Unit, Badalona, Spain
Germans Trias Hosp, IrsiCaixa AIDS Res Inst, Badalona, Spain
Raben, D:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Podlekareva, D:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Peters, L:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Lundgren, JD:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Mocroft, A:
Univ Copenhagen, Rigshosp, Ctr Excellence Hlth Immun & Infect, Dept Infect Dis,CHIP, Copenhagen, Denmark
Green Submitted, Green Published
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