Sarcoma classification by DNA methylation profiling.
Por:
Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig CE, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler KW, Reinhardt A, Wefers AK, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss FKF, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik AE, Kool M, Romero-Pérez L, Grünewald TGP, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers YMH, Weidema ME, Mentzel T, Griewank K, de Álava E, Martín JD, Gastearena MAI, Chang KT, Low SYY, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner VF, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens WNM, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado OM, Sáinz-Jaspeado M, Mora J, Alonso J, Del Muro XG, Moran S, Esteller M, Benhamida JK, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones DTW, Fröhling S, Pfister SM and von Deimling A
Publicada:
21 ene 2021
Ahead of Print:
21 ene 2021
Resumen:
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
Filiaciones:
Koelsche C:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Schrimpf D:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Stichel D:
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Sill M:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Sahm F:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Reuss DE:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Blattner M:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Worst B:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Heilig CE:
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Beck K:
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Heidelberg Center for Personalized Oncology (HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany
Horak P:
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Kreutzfeldt S:
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Paff E:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Stark S:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Johann P:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Selt F:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Ecker J:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Sturm D:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Pajtler KW:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Reinhardt A:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Wefers AK:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Sievers P:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Ebrahimi A:
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Suwala A:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Fernández-Klett F:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Casalini B:
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Korshunov A:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Hovestadt V:
Broad Institute of MIT and Harvard, Cambridge, MA, USA
Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Kommoss FKF:
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Kriegsmann M:
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Schick M:
Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Bewerunge-Hudler M:
Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Milde T:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Witt O:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Kulozik AE:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Kool M:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Romero-Pérez L:
Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
Grünewald TGP:
Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
Kirchner T:
Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
Wick W:
Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany
Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Platten M:
Department of Neurology, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Unterberg A:
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
Uhl M:
Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany
Abdollahi A:
Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany
Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany
Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
Debus J:
Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany
Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany
Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
Lehner B:
Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany
Thomas C:
Institute of Neuropathology, University Hospital Münster, Münster, Germany
Hasselblatt M:
Institute of Neuropathology, University Hospital Münster, Münster, Germany
Paulus W:
Institute of Neuropathology, University Hospital Münster, Münster, Germany
Hartmann C:
Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany
Staszewski O:
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Prinz M:
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany
Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany
Hench J:
Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland
Frank S:
Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland
Versleijen-Jonkers YMH:
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
Weidema ME:
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
Mentzel T:
Dermatopathology Bodensee, Friedrichshafen, Germany
Griewank K:
Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany
de Álava E:
Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC, Seville, Spain
Department of Normal and Pathological Cytology and Histology, School of Medicine. University of Seville, Seville, Spain
Martín JD:
Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC, Seville, Spain
Gastearena MAI:
Department of Pathological Anatomy, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
Chang KT:
Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore
Low SYY:
Department of Neurosurgery, National Neuroscience Institute, Singapore, Republic of Singapore
Cuevas-Bourdier A:
National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg
Mittelbronn M:
National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg
Luxembourg Center of Neuropathology (LCNP), Luxembourg, Luxembourg
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg
Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg
Mynarek M:
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Rutkowski S:
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Schüller U:
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
Mautner VF:
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Schittenhelm J:
Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany
Serrano J:
Department of Pathology, New York University School of Medicine, New York, NY, USA
Snuderl M:
Department of Pathology, New York University School of Medicine, New York, NY, USA
Büttner R:
Institute of Pathology, Cologne University Hospital, Cologne, Germany
Klingebiel T:
Department of Pediatric Hematology and Oncology, University Children's Hospital, Frankfurt/Main, Germany
Buslei R:
Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany
Gessler M:
Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Würzburg University, Würzburg, Germany
Wesseling P:
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands
Dinjens WNM:
Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Brandner S:
Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
Jaunmuktane Z:
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK
Lyskjær I:
Research Department of Pathology, University College London, London, UK
Schirmacher P:
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Stenzinger A:
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Brors B:
Division of Applied Bioinformatics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Glimm H:
Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Dresden, Germany
Center for Personalized Oncology, National Center for Tumor Diseases (NCT) Dresden and University Hospital Carl Gustav Carus Dresden at TU Dresden, Dresden, Germany
German Cancer Consortium (DKTK), Dresden, Germany
Heining C:
Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Dresden, Germany
Center for Personalized Oncology, National Center for Tumor Diseases (NCT) Dresden and University Hospital Carl Gustav Carus Dresden at TU Dresden, Dresden, Germany
German Cancer Consortium (DKTK), Dresden, Germany
Tirado OM:
Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC, Barcelona, Catalonia, Spain
Sáinz-Jaspeado M:
Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC, Barcelona, Catalonia, Spain
Mora J:
Department of Pediatric Onco-Hematology and Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain
Alonso J:
Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Del Muro XG:
Medical Oncology Service, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, Barcelona, Catalonia, Spain
Moran S:
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
:
Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain
Benhamida JK:
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Ladanyi M:
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Wardelmann E:
Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany
Antonescu C:
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Flanagan A:
Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK
University College London Cancer Institute, London, UK
Dirksen U:
Pediatrics III Pediatric Hematology, Oncology, Immunology, Cardiology, Pulmonology, West German Cancer Center, University Hospital Essen, Essen, Germany
International Ewing Sarcoma Study Group, German Cancer Consortium (DKTK), West German Cancer Center (WTZ), University Duisburg-Essen, Essen, Germany
Hohenberger P:
Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany
Baumhoer D:
Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland
Hartmann W:
Division of Translational Pathology, Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany
Vokuhl C:
Department of Pediatric Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany
Flucke U:
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
Petersen I:
Institute of Pathology, SRH Poliklinik Gera GmbH, Gera, Germany
Institute of Pathology, Jena University Hospital, Jena, Germany
Mechtersheimer G:
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Capper D:
Department of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany
Jones DTW:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Fröhling S:
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Pfister SM:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
von Deimling A:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
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