Critical appraisal and meta-analysis of biological variation estimates for kidney related analytes.
Por:
Jonker N, Aslan B, Boned B, Marqués-García F, Ricós C, Alvarez V, Bartlett W, Braga F, Carobene A, Coskun A, Diaz-Garzón J, Fernández-Calle P, Gonzalez-Lao E, Minchinela J, Perich C, Simón M, Sandberg S and Aarsand AK
Publicada:
28 mar 2022
Ahead of Print:
19 oct 2020
Resumen:
OBJECTIVES: Kidney markers are some of the most frequently used laboratory tests in patient care, and correct clinical decision making depends upon knowledge and correct application of biological variation (BV) data. The aim of this study was to review available BV data and to provide updated BV estimates for the following kidney markers in serum and plasma; albumin, creatinine, cystatin C, chloride, potassium, sodium and urea. CONTENT: Relevant studies were identified from a historical BV database as well as by systematic literature searches. Retrieved publications were appraised by the Biological Variation Data Critical Appraisal Checklist (BIVAC). Meta-analyses of BIVAC compliant studies with similar design were performed to deliver global estimates of within-subject (CV(I)) and between-subject (CV(G)) BV estimates. Out of the 61 identified papers, three received a BIVAC grade A, four grade B, 48 grade C, five grade D grade and one was not appraised as it did not report numerical BV estimates. Most studies were identified for creatinine (n=48). BV estimates derived from the meta-analysis were in general lower than previously reported estimates for all analytes except urea. For some measurands, BV estimates may be influenced by age or states of health, but further data are required. SUMMARY: This review provides updated global BV estimates for kidney related measurands. For all measurands except for urea, these estimates were lower than previously reported. OUTLOOK: For the measurands analyzed in this review, there are sufficient well-designed studies available to publish a trustworthy estimate of BV. However, for a number of newly appearing kidney markers no suitable data is available and additional studies are required.
Filiaciones:
Jonker N:
Certe-Wilhelmina Ziekenhuis Assen, Assen, The Netherlands
Aslan B:
Institute for Quality Management in Healthcare (IQMH), Centre for Proficiency Testing, Toronto, Ontario, Canada
Boned B:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Royo Villanova Hospital, Zaragoza, Spain
Marqués-García F:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Department of Clinical Biochemistry, University Hospital of Salamanca, Salamanca, Spain
Ricós C:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Alvarez V:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Bartlett W:
School of Medicine, University of Dundee, Dundee, Scotland, UK
Braga F:
Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy
Carobene A:
Servizio Medicina di Laboratorio, Ospedale San Raffaele, Milan, Italy
Coskun A:
Acibadem Mehmet Ali Aydinlar University, School of Medicine, Atasehir, Istanbul, Turkey
Diaz-Garzón J:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain
Fernández-Calle P:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Department of Laboratory Medicine, La Paz University Hospital, Madrid, Spain
Gonzalez-Lao E:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Quality Healthcare Consulting, Grupo ACMS, Madrid, Spain
:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Metropolitana Nord Unified Laboratory (LUMN), Germans Trias i Pujol University Hospital, Badalona, Spain
Perich C:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Simón M:
Spanish Society of Laboratory Medicine (SEQCML), Analytical Quality Commission, Barcelona, Spain
Consortium of Laboratory Intercomarcal Alt Penedès and Garraf l'Anoia, Vilafranca del Penedès, Spain
Sandberg S:
Norwegian Porphyria Centre, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway
Department of Global Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway
Aarsand AK:
Norwegian Porphyria Centre, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway
Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway
European Federation of Clinical Chemistry and Laboratory Medicine Working Group:
Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway
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