Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44
Por:
Shan, MM, Carrillo, J, Yeste, A, Gutzeit, C, Segura-Garzon, D, Walland, AC, Pybus, M, Grasset, EK, Yeiser, JR, Matthews, DB, van de Veen, W, Comerma, L, He, B, Boonpiyathad, T, Lee, H, Blanco, J, Osborne, LC, Siracusa, MC, Akdis, M, Artis, D, Mehandru, S, Sampson, HA, Berin, MC, Chen, K and Cerutti, A
Publicada:
16 oct 2018
Resumen:
B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the role of secreted IgD remains mysterious. We found that some B cells generated IgD-secreting plasma cells following early exposure to external soluble antigens such as food proteins. Secreted IgD targeted basophils by interacting with the CD44-binding protein galectin-9. When engaged by antigen, basophil-bound IgD increased basophil secretion of interleukin-4 (IL-4), IL-5, and IL-13, which facilitated the generation of T follicular helper type 2 cells expressing IL-4. These germinal center T cells enhanced IgG1 and IgE but not IgG2a and IgG2b responses to the antigen initially recognized by basophil-bound IgD. In addition, IgD ligation by antigen attenuated allergic basophil degranulation induced by IgE co-ligation. Thus, IgD may link B cells with basophils to optimize humoral T helper type 2-mediated immunity against common environmental soluble antigens.
Filiaciones:
Shan, MM:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
NIAID, MIST, NIH, Bethesda, MD 20982 USA
:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
UAB, IGTP, SIDA IrsiCaixa HIVACAT, Inst Recerca, Barcelona 08916, Spain
Yeste, A:
Inst Hosp Mar Invest Med IMIM, Program Inflammatory & Cardiovasc Disorders, Barcelona 08003, Spain
Gutzeit, C:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Segura-Garzon, D:
Inst Hosp Mar Invest Med IMIM, Program Inflammatory & Cardiovasc Disorders, Barcelona 08003, Spain
Walland, AC:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Pybus, M:
Inst Hosp Mar Invest Med IMIM, Program Inflammatory & Cardiovasc Disorders, Barcelona 08003, Spain
Grasset, EK:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Mol Med, S-17177 Stockholm, Sweden
Yeiser, JR:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Matthews, DB:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
van de Veen, W:
Univ Zurich, Swiss Inst Allergy & Asthma Res, Christine Kuhne Res Ctr Allergy & Educ, CH-7270 Davos, Switzerland
Comerma, L:
Inst Hosp Mar Invest Med IMIM, Program Inflammatory & Cardiovasc Disorders, Barcelona 08003, Spain
He, B:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Boonpiyathad, T:
Univ Zurich, Swiss Inst Allergy & Asthma Res, Christine Kuhne Res Ctr Allergy & Educ, CH-7270 Davos, Switzerland
Lee, H:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
:
UAB, IGTP, SIDA IrsiCaixa HIVACAT, Inst Recerca, Barcelona 08916, Spain
Univ Vic, UVIC UCC, Barcelona 08500, Spain
Osborne, LC:
Cornell Univ, Weill Med Coll, Jill Roberts Inst Res Inflammatory Bowel Dis, Dept Med, New York, NY 10021 USA
Siracusa, MC:
Rutgers New Jersey Med Sch, Dept Med, Ctr Immun & Inflammat, Newark, NJ 07103 USA
Akdis, M:
Univ Zurich, Swiss Inst Allergy & Asthma Res, Christine Kuhne Res Ctr Allergy & Educ, CH-7270 Davos, Switzerland
Artis, D:
NIAID, MIST, NIH, Bethesda, MD 20982 USA
Cornell Univ, Weill Med Coll, Jill Roberts Inst Res Inflammatory Bowel Dis, Dept Med, New York, NY 10021 USA
Mehandru, S:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Gastroenterol, New York, NY 10029 USA
Sampson, HA:
Icahn Sch Med Mt Sinai, Inst Immunol, Div Pediat Allergy & Immunol, New York, NY 10029 USA
Berin, MC:
Icahn Sch Med Mt Sinai, Inst Immunol, Div Pediat Allergy & Immunol, New York, NY 10029 USA
Chen, K:
NIAID, MIST, NIH, Bethesda, MD 20982 USA
Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA
Cerutti, A:
Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med, New York, NY 10029 USA
NIAID, MIST, NIH, Bethesda, MD 20982 USA
Inst Hosp Mar Invest Med IMIM, Program Inflammatory & Cardiovasc Disorders, Barcelona 08003, Spain
Catalan Inst Res & Adv Studies ICREA, Barcelona 08003, Spain
Green Accepted, Bronze
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