Circulating monocyte subsets and heart failure prognosis
Por:
Elchinova, E, Teubel, I, Roura, S, Fernandez, MA, Lupon, J, Galvez-Monton, C, de Antonio, M, Moliner, P, Domingo, M, Zamora, E, Nunez, J, Cediel, G and Bayes-Genis, A
Publicada:
21 sep 2018
Categoría:
Multidisciplinary
Resumen:
Monocytes are a heterogeneous population of effector cells with key roles in tissue integrity restoration and maintenance. Here, we explore the association of monocyte subsets and prognosis in patients with ambulatory heart failure (HF). Monocyte subsets were classified as classical (CD14(++)/CD16(-)), intermediate (CD14(++)/CD16(+)), or non-classical (CD14(+)/CD16(++)). Percentage distribution and absolute cell count were assessed in each subset, and multivariable Cox regression analyses were performed with all-cause death, HF-related hospitalization, and the composite end-point of both as dependent variables. 400 patients were consecutively included (72.8% male, age 69.4 +/- 12.2 years, 45.5% from ischemic aetiology, left ventricle ejection fraction (LVEF) 41.6% +/- 14.5, New York Heart Association (NYHA) class II 62.8% and III 30.8%). During a mean follow-up of 2.6 +/- 0.9 years, 107 patients died, 99 had a HF-related hospitalization and 160 suffered the composite end-point of all-cause death or HF-related hospitalization. Monocyte subsets assessed in percentages were not independently associated to any of the end-points. When considering number of cells/mu L, intermediate subset was independently associated with an increase of all-cause death (HR 1.25 [95% CI 1,02-1.52], p = 0.03), and the composite end-point HR 1.20 [95% CI 1,03-1.40], p = 0.02). The presented findings show that absolute cell count of monocyte subsets was preferred over monocyte percentage for prognosis stratification for outpatients with HF. The intermediate monocyte subset provides information on increased risk of allcause death and the composite end-point.
Filiaciones:
Elchinova, E:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Univ Hosp, Inselspital, Bern, Switzerland
Teubel, I:
Germans Trias & Pujol Hlth Sci Res Inst, Flow Cytometry Facil, Badalona, Spain
:
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Germans Trias & Pujol Hlth Sci Res Inst, ICREC Res Program, Badalona, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst, Flow Cytometry Facil, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
:
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Germans Trias & Pujol Hlth Sci Res Inst, ICREC Res Program, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Nunez, J:
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Univ Valencia, Hosp Clin Univ, Cardiol Dept, INCLIVA, Valencia, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp, Heart Failure Unit, Badalona, Spain
Germans Trias & Pujol Univ Hosp, Cardiol Serv, Badalona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Germans Trias & Pujol Hlth Sci Res Inst, ICREC Res Program, Badalona, Spain
Green Published, Green Submitted, gold
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