Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
Por:
Kuypers, KPC, de la Torre, R, Farre, M, Xicota, L, Perna, EBDF, Theunissen, EL and Ramaekers, JG
Publicada:
18 ene 2018
Categoría:
Multidisciplinary
Resumen:
MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant ('s-group') of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele ('l-group'). The present study aimed to investigate the role of the 5-HTTLPR polymorphism in MDMA-induced mood effects. Four placebo-controlled, within-subject studies were pooled, including in total 63 polydrug ecstasy users (Ns-group = 48; Nl-group = 15) receiving MDMA 75 mg and placebo on two test days, separated by minimally 7 days. Mood was assessed by means of the Profile of Mood States. Findings showed that MDMA induced -independent of sex-a positive mood state, and as a side effect also increased two negative affect states, anxiety and confusion. Anxiety ratings were higher in the l-group and independent of treatment or sex. Depression ratings were lowered by MDMA in the female l-group. Findings indicate that the MDMA-induced reduction in self-rated depressive feelings is sex- and genotype-dependent, with females homozygous for the l-allele showing this beneficial effect.
Filiaciones:
Kuypers, KPC:
Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands
de la Torre, R:
Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Santiago De Compostela, Spain
Univ Pompeu Fabra, CEXS UPF, Barcelona, Spain
:
Inst Hosp del Mar Invest Med, Integrat Pharmacol & Neurosci Syst Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Clin Pharmacol, Badalona, Spain
Xicota, L:
Inst Hosp del Mar Invest Med, Integrat Pharmacol & Neurosci Syst Res Grp, Barcelona, Spain
Perna, EBDF:
Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands
Theunissen, EL:
Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands
Ramaekers, JG:
Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands
Green Published, gold
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