Variants of core histones and their roles in cell fate decisions, development and cancer
Por:
Buschbeck, M and Hake, SB
Publicada:
1 may 2017
Resumen:
Histone variants endow chromatin with unique properties and show a specific genomic distribution that is regulated by specific deposition and removal machineries. These variants - in particular, H2A.Z, macroH2A and H3.3 - have important roles in early embryonic development, and they regulate the lineage commitment of stem cells, as well as the converse process of somatic cell reprogramming to pluripotency. Recent progress has also shed light on how mutations, transcriptional deregulation and changes in the deposition machineries of histone variants affect the process of tumorigenesis. These alterations promote or even drive cancer development through mechanisms that involve changes in epigenetic plasticity, genomic stability and senescence, and by activating and sustaining cancer-promoting gene expression programmes.
Filiaciones:
:
Josep Carreras Leukaemia Res Inst, Campus Inst Catala Oncol Germans Trias & Pujol, Badalona 08916, Spain
Germans Trias & Pujol Res Inst, Program Predict & Personalized Med Canc, Badalona 08916, Spain
Hake, SB:
Ludwig Maximilians Univ Munchen, Ctr Integrated Prot Sci Munich, D-82152 Planegg Martinsrie, Germany
Ludwig Maximilians Univ Munchen, BioMed Ctr, Dept Mol Biol, D-82152 Planegg Martinsrie, Germany
Justus Liebig Univ Giessen, Inst Genet, D-35392 Giessen, Germany
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