Transgenerational transmission of environmental information in C-elegans
Por:
Klosin, A, Casas, E, Hidalgo-Carcedo, C, Vavouri, T and Lehner, B
Publicada:
21 abr 2017
Resumen:
The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis elegans heterochromatic gene array can endure for at least 14 generations. Inheritance is primarily in cis with the locus, occurs through both oocytes and sperm, and is associated with altered trimethylation of histone H3 lysine 9 (H3K9me3) before the onset of zygotic transcription. Expression profiling reveals that temperature-induced expression from endogenous repressed repeats can also be inherited for multiple generations. Long-lasting epigenetic memory of environmental change is therefore possible in this animal.
Filiaciones:
Klosin, A:
European Mol Biol Org, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 08003, Spain
Univ Pompeu Fabra, Barcelona 08003, Spain
Casas, E:
Inst Germans Trias & Pujol, Program Predict & Personalized Med Canc, Campus Can Ruti, Barcelona 08916, Spain
Hidalgo-Carcedo, C:
European Mol Biol Org, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 08003, Spain
Univ Pompeu Fabra, Barcelona 08003, Spain
:
Inst Germans Trias & Pujol, Program Predict & Personalized Med Canc, Campus Can Ruti, Barcelona 08916, Spain
Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain
Lehner, B:
European Mol Biol Org, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 08003, Spain
Univ Pompeu Fabra, Barcelona 08003, Spain
Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain
Green Accepted
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