Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
Por:
Martinez, I, Oliveros, JC, Cuesta, I, de la Barrera, J, Ausina, V, Casals, C, de Lorenzo, A, Garcia, E, Garcia-Fojeda, B, Garmendia, J, Gonzalez-Nicolau, M, Lacoma, A, Menendez, M, Moranta, D, Nieto, A, Ortin, J, Perez-Gonzalez, A, Prat, C, Ramos-Sevillano, E, Regueiro, V, Rodriguez-Frandsen, A, Solis, D, Yuste, J, Bengoechea, JA and Melero, JA
Publicada:
1 mar 2017
Resumen:
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
Filiaciones:
Martinez, I:
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Oliveros, JC:
CSIC, Ctr Nacl Biotecnol, Madrid, Spain
Cuesta, I:
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
de la Barrera, J:
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
Ausina, V:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Microbiol Serv, Barcelona, Spain
Casals, C:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Complutense, Dept Bioquim & Biol Mol 1, Madrid, Spain
de Lorenzo, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Complutense, Dept Bioquim & Biol Mol 1, Madrid, Spain
Garcia, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Ctr Invest Biol, Madrid, Spain
Garcia-Fojeda, B:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Garmendia, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Publ Navarra Gob, CSIC, Inst Agrobiotecnol, Navarra, Spain
Gonzalez-Nicolau, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Microbiol Serv, Barcelona, Spain
Menendez, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Moranta, D:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Fdn Invest Sanitaria Islas Baleares, Inst Invest Sanitaria Palma, Sanitaria De Palma, Palma, Spain
Univ Illes Balears, Dept Biol, Palma De Mallorca, Islas Baleares, Spain
Nieto, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Ctr Nacl Biotecnol, Madrid, Spain
Ortin, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Ctr Nacl Biotecnol, Madrid, Spain
Perez-Gonzalez, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Prat, C:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Ramos-Sevillano, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Ctr Invest Biol, Madrid, Spain
Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England
Regueiro, V:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Fdn Invest Sanitaria Islas Baleares, Inst Invest Sanitaria Palma, Sanitaria De Palma, Palma, Spain
Rodriguez-Frandsen, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Solis, D:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Inst Quim Fis Rocasolano, Madrid, Spain
Yuste, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
CSIC, Ctr Invest Biol, Madrid, Spain
Bengoechea, JA:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Queens Univ Belfast, Ctr Med Expt, Belfast, Antrim, North Ireland
Melero, JA:
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
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