Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles
Por:
Reiner, AT, Witwer, KW, van Balkom, BWM, de Beer, J, Brodie, C, Corteling, RL, Gabrielsson, S, Gimona, M, Ibrahim, AG, de Kleijn, D, Lai, CP, Lotvall, J, del Portillo, HA, Reischl, IG, Riazifar, M, Salomon, C, Tahara, H, Toh, WS, Wauben, MHM, Yang, VK, Yang, YJ, Yeo, RWY, Yin, H, Giebel, B, Rohde, E and Lim, SK
Publicada:
1 ago 2017
Resumen:
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies.
Filiaciones:
Reiner, AT:
AIT Austrian Inst Technol, BioSensor Technol, Vienna, Austria
Witwer, KW:
Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
van Balkom, BWM:
Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, Utrecht, Netherlands
de Beer, J:
Anjarium Biosciences AG, Zollikon, Switzerland
Brodie, C:
Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA
Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel
Corteling, RL:
ReNeuron Grp, Pencoed, Wales
Gabrielsson, S:
Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden
Gimona, M:
PMU, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Strubergasse 22, A-5020 Salzburg, Austria
Salzburger Landeskliniken GesmbH SALK, Univ Hosp, Dept Blood Grp Serol & Transfus Med, Salzburg, Austria
Ibrahim, AG:
Capricor Therapeut, Los Angeles, CA USA
de Kleijn, D:
Univ Utrecht, Dept Vasc Surg & Cardiol, Utrecht, Netherlands
NUS Surg & A STAR, Singapore, Singapore
Lai, CP:
Natl Tsing Hua Univ, Inst Biomed Engn, Hsinchu, Taiwan
Lotvall, J:
Gothenburg Univ, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden
Codiak BioSci, Woburn, MA USA
:
Univ Barcelona, Hosp Clin, ICREA ISGlobal Barcelona Inst Global Hlth, Barcelona, Spain
Inst Invest Germans Trias & Pujol IGTP, Badalona, Spain
Reischl, IG:
Fed Off Safety Hlth Care, Vienna, Austria
Austrian Agcy Hlth & Food Safety, Inst Surveillance, Vienna, Austria
Riazifar, M:
Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA
Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA USA
Salomon, C:
Univ Queensland, Royal Brisbane & Womens Hosp, Ctr Clin Res, Brisbane, Qld, Australia
Ochsner Clin Fdn, Dept Obstet & Gynecol, New Orleans, LA USA
Tahara, H:
Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Cellular & Mol Biol, Hiroshima, Japan
Toh, WS:
Natl Univ Singapore, Fac Dent, Singapore, Singapore
Wauben, MHM:
Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Utrecht, Netherlands
Yang, VK:
Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA
Yang, YJ:
Chinese Acad Sci, State Key Lab Resp Dis Guangzhou Inst Biomed & Hl, Guangzhou, Guangdong, Peoples R China
Yeo, RWY:
ASTAR, Inst Med Biol, 8A Biomed Grove,05-505 Immunos, Singapore 138648, Singapore
Yin, H:
Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA
Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
Tsinghua Univ, Dept Chem, CBMS, Beijing, Peoples R China
Giebel, B:
Univ Duisburg Essen, Univ Hosp Essen, Inst Transfus Med, Duisburg, Germany
Rohde, E:
PMU, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Strubergasse 22, A-5020 Salzburg, Austria
Salzburger Landeskliniken GesmbH SALK, Univ Hosp, Dept Blood Grp Serol & Transfus Med, Salzburg, Austria
Lim, SK:
ASTAR, Inst Med Biol, 8A Biomed Grove,05-505 Immunos, Singapore 138648, Singapore
Green Published, gold
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