Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism


Por: Arno, AG, Farre, M, Rodriguez-Morato, J, Ramon, JM, Perez-Mana, C, Papaseit, E, Civit, E, Langohr, K, li Carbo, M, Boix, DB, Nino, OC, Le Roux, JAF, Pera, M, Grande, L and de la Torre, R

Publicada: 1 dic 2017
Resumen:
The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).

Filiaciones:
Arno, AG:
 Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain

 Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain

 Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain

:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, IGTP, Badalona, Spain

Rodriguez-Morato, J:
 Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain

 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

Ramon, JM:
 Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain

Perez-Mana, C:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain

:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, IGTP, Badalona, Spain

Civit, E:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

Langohr, K:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain

li Carbo, M:
 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Univ Pompeu Fabra, Dept Expt & Hlth Sci, CEXS UPF, Dr Aiguader 80, Barcelona 08003, Spain

Boix, DB:
 Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain

 Autonomous Univ Barcelona, Dept Med, Barcelona, Spain

 Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain

Nino, OC:
 Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain

 Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain

Le Roux, JAF:
 Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain

 Autonomous Univ Barcelona, Dept Med, Barcelona, Spain

 Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain

Pera, M:
 Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain

Grande, L:
 Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain

de la Torre, R:
 Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain

 Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain

 Univ Pompeu Fabra, Dept Expt & Hlth Sci, CEXS UPF, Dr Aiguader 80, Barcelona 08003, Spain
ISSN: 09608923





Obesity Surgery
Editorial
Springer New York LLC, ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES, Estados Unidos America
Tipo de documento: Article
Volumen: 27 Número: 12
Páginas: 3194-3201
WOS Id: 000416562700016
ID de PubMed: 28560524
imagen Green Submitted, Green Accepted

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