Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism
Por:
Arno, AG, Farre, M, Rodriguez-Morato, J, Ramon, JM, Perez-Mana, C, Papaseit, E, Civit, E, Langohr, K, li Carbo, M, Boix, DB, Nino, OC, Le Roux, JAF, Pera, M, Grande, L and de la Torre, R
Publicada:
1 dic 2017
Resumen:
The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function).
In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study.
Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery.
Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).
Filiaciones:
Arno, AG:
Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain
Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain
Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain
:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, IGTP, Badalona, Spain
Rodriguez-Morato, J:
Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Ramon, JM:
Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain
Perez-Mana, C:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain
:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, IGTP, Badalona, Spain
Civit, E:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Langohr, K:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain
li Carbo, M:
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Univ Pompeu Fabra, Dept Expt & Hlth Sci, CEXS UPF, Dr Aiguader 80, Barcelona 08003, Spain
Boix, DB:
Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain
Nino, OC:
Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain
Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain
Le Roux, JAF:
Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, IMIM, Res Inst, Dr Aiguader 88, Barcelona 08003, Spain
Pera, M:
Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain
Grande, L:
Hosp del Mar, Sect Gastrointestinal Surg, Barcelona, Spain
de la Torre, R:
Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain
Hosp del Mar, Integrat Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program, IMIM,Res Inst, Doctor Aiguader 88,Off 217, Barcelona 08003, Spain
Univ Pompeu Fabra, Dept Expt & Hlth Sci, CEXS UPF, Dr Aiguader 80, Barcelona 08003, Spain
Green Submitted, Green Accepted
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