Adiposity and Diabetes Risk in Adults with Prediabetes: Heterogeneity of Findings Depending on Age and Anthropometric Measure
Por:
Giraldez-Garcia, C, Franch-Nadal, J, Sangros, FJ, Ruiz, A, Carraminana, F, Goday, A, Villaro, M, Garcia-Soidan, FJ, Serrano, R and Regidor, E
Publicada:
1 sep 2018
Resumen:
Objective: This study aimed to evaluate the effect of age on diabetes incidence by general and central adiposity after 3-year follow-up in adults with prediabetes.
Methods: Data were taken from a cohort of 1,184 subjects with prediabetes included in The Cohort Study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS). General adiposity was defined using body mass index (BMI), and central adiposity was defined with waist circumference and waist to height ratio. Data were analyzed by age groups 30 to 59 and 60 to 74 years. The association between adiposity and diabetes incidence was assessed using hazard ratios (HR).
Results: Adjusting for sociodemographic characteristics, lifestyles, and metabolic parameters, diabetes HR for central adiposity based on the waist circumference clinical cutoff were 2.14 (1.12-4.09) and 1.48 (0.80-2.74) for people aged 30 to 59 and 60 to 74 years, respectively. In the model additionally adjusted for BMI, diabetes HR were 2.65 (1.24-5.65) and 1.33 (0.68-2.59), respectively. The use of a 1-SD increase rather than cutoff points did not alter this pattern. Similar findings were observed with central adiposity based on waist to height ratio.
Conclusions: The association of central adiposity with type 2 diabetes incidence was lower for people in the older age group than for those in the younger age group.
Filiaciones:
Giraldez-Garcia, C:
RedGDPS Fdn, Madrid, Spain
Infanta Elena Univ Hosp, Madrid, Spain
:
RedGDPS Fdn, Madrid, Spain
Univ Inst Res Primary Care Jordi Gol, Barcelona City Res Support Unit, Barcelona, Spain
Biomed Res Networking Ctr Consortium Diabet & Ass, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Sangros, FJ:
RedGDPS Fdn, Madrid, Spain
Torrero La Paz Hlth Ctr, Zaragoza, Spain
Ruiz, A:
RedGDPS Fdn, Madrid, Spain
Pinto Hlth Ctr, Madrid, Spain
Carraminana, F:
RedGDPS Fdn, Madrid, Spain
San Roque Hlth Ctr, Badajoz, Spain
Goday, A:
RedGDPS Fdn, Madrid, Spain
Hosp del Mar, Dept Endocrinol, Barcelona, Spain
Villaro, M:
RedGDPS Fdn, Madrid, Spain
Terrassa Sud Primary Care Ctr, Barcelona, Spain
Garcia-Soidan, FJ:
RedGDPS Fdn, Madrid, Spain
Porrino Hlth Ctr, Pontevedra, Spain
Serrano, R:
RedGDPS Fdn, Madrid, Spain
Martin de Vargas Hlth Ctr, Madrid, Spain
Regidor, E:
RedGDPS Fdn, Madrid, Spain
Biomed Res Networking Ctr Consortium Publ Hlth &, Madrid, Spain
Univ Complutense Madrid, Dept Prevent Med Publ Hlth & Hist Sci, Madrid, Spain
Hosp Clin San Carlos, Inst Hlth Res, Madrid, Spain
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