Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result
Por:
Arellano, AL, Martin-Subero, M, Monerris, M, LLerena, A, Farre, M and Montane, E
Publicada:
1 nov 2017
Categoría:
Medicine (miscellaneous)
Resumen:
Rationale:Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6.Patient concerns:We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period.Interventions and Outcomes:A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency.Lessons:Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.
Filiaciones:
Arellano, AL:
Hosp Badalona Germans Trias & Pujol, Dept Clin Pharmacol, Carretera Canyet S-N, Badalona 08916, Barcelona, Spain
Univ Autonoma Barcelona, Dept Pharmacol Therapeut & Toxicol, Barcelona, Spain
Martin-Subero, M:
Hosp Badalona Germans Trias & Pujol, Dept Psychiat, Barcelona, Spain
FIDMAG Res Fdn, Barcelona, Spain
Monerris, M:
Hosp Badalona Germans Trias & Pujol, Pain Unit, Dept Anesthesiol & Reanimat, Barcelona, Spain
LLerena, A:
Extremadura Univ Hosp & Med Sch, CICAB Clin Res Ctr, Badajoz, Spain
:
Hosp Badalona Germans Trias & Pujol, Dept Clin Pharmacol, Carretera Canyet S-N, Badalona 08916, Barcelona, Spain
Univ Autonoma Barcelona, Dept Pharmacol Therapeut & Toxicol, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Dept Clin Pharmacol, Carretera Canyet S-N, Badalona 08916, Barcelona, Spain
Univ Autonoma Barcelona, Dept Pharmacol Therapeut & Toxicol, Barcelona, Spain
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