ENDOCRINE OBESITY Pituitary dysfunction in obesity
Por:
Ruiz, S, Vazquez, F, Pellitero, S and Puig-Domingo, M
Publicada:
1 jun 2022
Resumen:
Obesity, the growing pandemic of the 21st century, is associated with multiple organ dysfunction, either by a direct increase in fatty organ content or by indirect modifications related to general metabolic changes driven by a specific increase in biologic products. The pituitary gland is not protected against such a situation. Different hypothalamic-pituitary axes experience functional modifications initially oriented to an adaptive situation that, with years of obesity, turn to maladaptive dynamics that contribute to perpetuating obesity and specific symptoms of their hormonal nature. This paper reviews the recent knowledge on obesity-related pituitary dysfunction and its pathogenic mechanisms and discusses potential therapeutic actions aimed at contributing to ameliorating the complex treatment of severe cases of obesity.
Filiaciones:
Ruiz, S:
Germans Trias & Pujol Univ Hosp & Res Inst, Dept Endocrinol & Nutr, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp & Res Inst, Dept Endocrinol & Nutr, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp & Res Inst, Dept Endocrinol & Nutr, Badalona, Spain
:
Germans Trias & Pujol Univ Hosp & Res Inst, Dept Endocrinol & Nutr, Badalona, Spain
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