Three-dimensional genome organization in immune cell fate and function
Por:
Cuartero, S, Stik, G and Stadhouders, R
Ahead of Print:
1 sep 2022
Resumen:
Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization of the genome has emerged as an important regulator of chromatin state, transcriptional activity and cell identity by facilitating or impeding long-range genomic interactions among regulatory elements and genes. Chromatin folding thus enables cell type-specific and stimulus-specific transcriptional responses to extracellular signals, which are essential for the control of immune cell fate, for inflammatory responses and for generating a diverse repertoire of antigen receptor specificities. Here, we review recent findings connecting 3D genome organization to the control of immune cell differentiation and function, and discuss how alterations in genome folding may lead to immune dysfunction and malignancy.
Three-dimensional (3D) genome organization has emerged as an important regulator of gene expression and genomic interaction. Here, the authors explain how 3D genome organization impacts immune cell development and function, and discuss how aberrant genome folding can contribute to immune-mediated disease and cancer.
Filiaciones:
:
Josep Carreras Leukaemia Res Inst IJC, Badalona, Spain
Germans Trias & Pujol Res Inst IGTP, Badalona, Spain
Stik, G:
Inst Sci & Technol BIST, Ctr Genom Regulat CRC, Barcelona, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Stadhouders, R:
Erasmus MC, Univ Med Ctr, Dept Pulm Med, Rotterdam, Netherlands
Erasmus MC, Univ Med Ctr, Dept Cell Biol, Rotterdam, Netherlands
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