How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
Por:
Betancor, D, Olaguibel, JM, Rodrigo-Munoz, JM, Arismendi, E, Barranco, P, Barroso, B, Bobolea, I, Cardaba, B, Cruz, MJ, Curto, E, Del Pozo, V, Gonzalez-Barcala, FJ, Martinez-Rivera, C, Mullol, J, Munoz, X, Picado, C, Plaza, V, Quirce, S, Rial, MJ, Soto, L, Valero, A, Valverde-Monge, M and Sastre, J
Publicada:
1 ago 2022
Resumen:
Background and Aims Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. Materials and Methods We assessed the concordance between the algorithm proposed by Heany et al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity. Results No correlation was found between both classifications 0.025 (CI = 0.013-0.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population. Discussion and Conclusion In conclusion, our results suggest that grouping the biomarkers proposed by Heany et al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.
Filiaciones:
Betancor, D:
Hosp Univ Fdn Jimenez Diaz, Serv Alergol, Madrid, Spain
Olaguibel, JM:
Hosp Univ Navarra, Serv Alergol, Pamplona, Navarra, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Rodrigo-Munoz, JM:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Univ Fdn Jimenez Diaz, Inst Invest Sanitaria, Serv Inmunol, Madrid, Spain
Arismendi, E:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Barcelona, IDIBAPS, Allergy Unit, Barcelona, Spain
Univ Barcelona, Hosp Clin, IDIBAPS, Severe Asthma Unit,Pneumonol & Allergy Dept, Barcelona, Spain
Barranco, P:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Univ La Paz, IdiPAZ, Serv Alergia, Madrid, Spain
Barroso, B:
Hosp Univ Fdn Jimenez Diaz, Serv Alergol, Madrid, Spain
Bobolea, I:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Barcelona, IDIBAPS, Allergy Unit, Barcelona, Spain
Univ Barcelona, Hosp Clin, IDIBAPS, Severe Asthma Unit,Pneumonol & Allergy Dept, Barcelona, Spain
Cardaba, B:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Univ Fdn Jimenez Diaz, Inst Invest Sanitaria, Serv Inmunol, Madrid, Spain
Cruz, MJ:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Dept Biol Celular Fisiol & Inmunol, Barcelona, Spain
Curto, E:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Dept Med Resp, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB St Pau,Dept Med, Barcelona, Spain
Del Pozo, V:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Univ Fdn Jimenez Diaz, Inst Invest Sanitaria, Serv Inmunol, Madrid, Spain
Gonzalez-Barcala, FJ:
Complejo Hosp Univ Santiago, Serv Neumol, La Coruna, Spain
:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Inst Invest Germans Trias & Pujol, Hosp Germans Trias & Pujol, Serv Neumol, Barcelona, Spain
Mullol, J:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Barcelona, Rhinol Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Smell Clin, ENT Dept, Clin & Expt Resp Immunoallergy IDIBAPS, Barcelona, Catalonia, Spain
Munoz, X:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Vall dHebron Barcelona, Serv Neumol, Barcelona, Spain
Picado, C:
Univ Barcelona, IDIBAPS, Allergy Unit, Barcelona, Spain
Univ Barcelona, Hosp Clin, IDIBAPS, Severe Asthma Unit,Pneumonol & Allergy Dept, Barcelona, Spain
Plaza, V:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Dept Med Resp, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB St Pau,Dept Med, Barcelona, Spain
Quirce, S:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Hosp Univ La Paz, IdiPAZ, Serv Alergia, Madrid, Spain
Rial, MJ:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Complexo Hosp Univ A Coruna, Serv Alergol, La Coruna, Spain
Soto, L:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Autonoma Barcelona, Dept Med Resp, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB St Pau,Dept Med, Barcelona, Spain
Valero, A:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Barcelona, IDIBAPS, Allergy Unit, Barcelona, Spain
Univ Barcelona, Hosp Clin, IDIBAPS, Severe Asthma Unit,Pneumonol & Allergy Dept, Barcelona, Spain
Valverde-Monge, M:
Hosp Univ Fdn Jimenez Diaz, Serv Alergol, Madrid, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Sastre, J:
Hosp Univ Fdn Jimenez Diaz, Serv Alergol, Madrid, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
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