Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study
Por:
Violan, C, Toran-Monserrat, P, Quirant, B, Lamonja-Vicente, N, Carrasco-Ribelles, LA, Chacon, C, Manresa-Dominguez, JM, Ramos-Roure, F, Dacosta-Aguayo, R, Palacios-Fernandez, C, Roso-Llorach, A, Pujol, A, Ouchi, D, Monteagudo, M, Montero-Alia, P, Garcia-Sierra, R, Armestar, F, Dolade, M, Prat, N, Bonet, JM, Clotet, B, Blanco, I, Boigues-Pons, M, Moreno-Millan, N, Prado, JG and Caceres, EMM
Publicada:
3 sep 2022
Resumen:
Background Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months. Methods We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model included factors of time, gender, and disease severity (asymptomatic, mild-moderate, severe-critical) to assess their effects and their interactions. Findings 474 of the 769 participants (61.6%) became infected with SARS-CoV-2. Significant effects of gender and disease severity were found for the levels of all three antibodies. Median IgM(N) levels were already below the positivity threshold in patients with asymptomatic and mild-moderate disease at day 270 after the diagnosis, while IgG(N and S) levels remained positive at least until days 450 and 270, respectively. Kinetic modelling showed a general rise in both IgM(N) and IgG(N) levels up to day 30, followed by a decay with a rate depending on disease severity. IgG(S) levels remained relatively constant from day 15 over time. Interpretation IgM(N) and IgG(N, S) SARS-CoV-2 antibodies showed a heterogeneous kinetics over the 17 months. Only the IgG(S) showed a stable increase, and the levels and the kinetics of antibodies varied according to disease severity. The kinetics of IgM and IgG observed over a year also varied by clinical spectrum can be very useful for public health policies around vaccination criteria in adult population. Funding Regional Ministry of Health of the Generalitat de Catalunya (Call COVID19-PoC SLT16_04; NCT04885478).
Filiaciones:
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Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona, Cerdanyola Del Valles, Spain
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Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Univ Girona, Fac Med, Dept Med, Girona 17003, Spain
Multidisciplinary Res Grp Hlth & Soc GREMSAS 2017, Barcelona 08007, Spain
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Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona, FOCIS Ctr Excellence, Cell Biol Physiol Immunol Dept, Cerdanyola Del Valles, Spain
Hosp Badalona Germans Trias & Pujol, Immunol Div, Lab Clin Metropolitana Nord LCMN, Badalona, Spain
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Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Carrasco-Ribelles, LA:
Fundacio Inst Univ Invest Atencio Primaria Jordi, Barcelona, Spain
Chacon, C:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Immunol Div, Lab Clin Metropolitana Nord LCMN, Badalona, Spain
Univ Autonoma Barcelona, Dept Nursing, Cerdanyola Del Valles, Spain
Ramos-Roure, F:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Univ Autonoma Barcelona, Fac Med, Dept Med, Bellaterra 08193, Spain
:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Palacios-Fernandez, C:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Roso-Llorach, A:
Fundacio Inst Univ Invest Atencio Primaria Jordi, Barcelona, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent, Bellaterra 08193, Spain
Pujol, A:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Ouchi, D:
Fundacio Inst Univ Invest Atencio Primaria Jordi, Barcelona, Spain
AIDS Res Inst IrsiCaixa, Badalona, Spain
Monteagudo, M:
Fundacio Inst Univ Invest Atencio Primaria Jordi, Barcelona, Spain
Montero-Alia, P:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Univ Girona, Fac Med, Dept Med, Girona 17003, Spain
Inst Catala Salut, Ctr Atencio Primaria Riera Mataro 1, Barcelona, Spain
:
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare Deu Guadalupe 2,Planta 1, Barcelona 08303, Spain
Univ Girona, Fac Med, Dept Med, Girona 17003, Spain
Univ Autonoma Barcelona, Dept Nursing, Cerdanyola Del Valles, Spain
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Univ Autonoma Barcelona, Cerdanyola Del Valles, Spain
Hosp Badalona Germans Trias & Pujol, Intens Care Unit, Badalona, Spain
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Hosp Badalona Germans Trias & Pujol, Lab Clin Metropolitana Nord LCMN, Clin & Biochem Anal Div, Badalona, Spain
Prat, N:
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
Bonet, JM:
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
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Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
AIDS Res Inst IrsiCaixa, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
Univ Vic, Cent Univ Catalonia UVic UCC, Vic 08500, Spain
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Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Inst Catala Salut, Gerencia Terr Metropolitana Nord, Barcelona, Spain
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Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona, FOCIS Ctr Excellence, Cell Biol Physiol Immunol Dept, Cerdanyola Del Valles, Spain
Hosp Badalona Germans Trias & Pujol, Immunol Div, Lab Clin Metropolitana Nord LCMN, Badalona, Spain
Moreno-Millan, N:
Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Barcelona, Spain
:
Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
AIDS Res Inst IrsiCaixa, Badalona, Spain
Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid, Spain
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Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona, FOCIS Ctr Excellence, Cell Biol Physiol Immunol Dept, Cerdanyola Del Valles, Spain
Hosp Badalona Germans Trias & Pujol, Immunol Div, Lab Clin Metropolitana Nord LCMN, Badalona, Spain
Univ Autonoma Barcelona, Fac Med, Dept Med, Bellaterra 08193, Spain
Green Published, Green Submitted, gold
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