FDG-PET/CT-guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma
Por:
Rajamaki, A, Kuitunen, H, Sorigue, M, Kokkonen, SM, Kuittinen, O and Sunela, K
Publicada:
1 ene 2023
Ahead of Print:
1 jun 2022
Resumen:
Aim: The purpose of the study was to evaluate the clinical impact of flu orodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL).
Methods: This retrospective study included all the patients who had undergone FDG-PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital.
Results: The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG-PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified TIT had no previous clinical suspicion of transformation.
Conclusion: Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG-PET/CT is valuable in detecting clinically unsuspected HT of FL.
Filiaciones:
Rajamaki, A:
Hosp Nova Cent Finland, Dept Oncol, Keskussairaalantie 19, Jyvaskyla 40620, Finland
Univ Eastern Finland, Fac Hlth Med, Inst Clin Med, Kuopio, Finland
Kuitunen, H:
Oulu Univ Hosp, Dept Oncol, Oulu, Finland
:
ICO Hosp Germans Trias & Pujol, Dept Hematol, Funct Cyt IJC, Badalona, Spain
Kokkonen, SM:
Oulu Univ Hosp, Dept Nucl Med, Oulu, Finland
Kuittinen, O:
Univ Eastern Finland, Fac Hlth Med, Inst Clin Med, Kuopio, Finland
Univ Oulu, Med Res Ctr, Oulu, Finland
Univ Oulu, Canc & Translat Res Unit, Oulu, Finland
Oulu Univ Hosp, Oulu, Finland
Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland
Sunela, K:
Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland
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