Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data

Por: Giorgi-Pierfranceschi, M, Monreal, M, Di Micco, P, Francisco, I, Hernandez-Blasco, L, Madridano, O, Lopez-Saez, JB, Hernando, E, Meireles, J and Dentali, F

Publicada: 1 feb 2022
Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbolica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19-1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02-1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96-1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22-1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms.

Giorgi-Pierfranceschi, M: Ist Ospitalieri Cremona, Dept Internal Med, I-26100 Cremona, Italy
Monreal, M: Univ Catolica Murcia, Hosp Germans Trias & Pujol, Dept Internal Med, Barcelona 08016, Spain
Di Micco, P: Osped Buon Consiglio Fatebenefratelli, Dept Internal Med & Emergency Room, I-80122 Naples, Italy
Francisco, I: Hosp Univ Girona Dr Josep Trueta, Dept Internal Med, Girona 17007, Spain
Hernandez-Blasco, L: Hosp Gen Univ Alicante, ISABIAL, Dept Pneumonol, UMH, Alicante 03014, Spain
Madridano, O: Hosp Univ Infanta Sofia, Dept Internal Med, Madrid 28042, Spain
Lopez-Saez, JB: Hosp Univ Puerto Real, Dept Internal Med, Cadiz 11006, Spain
Hernando, E: Hosp San Pedro, Dept Pneumonol, Logrono 26001, Spain
Meireles, J: Centro Hospitalar Entre Douro & Vouga, Dept Internal Med, P-4520195 Santa Maria Feira, Portugal
Dentali, F: Insubria Univ, Dept Med & Surg, I-21100 Varese, Italy
ISSN: 16489144

Kauno Medicinos Universitetas, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Lituania
Tipo de documento: Article
Volumen: 58 Número: 2
WOS Id: 000769679900001
ID de PubMed: 35208618
imagen Green Published, gold