Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018
Por:
Mir-Cros, A, Moreno-Mingorance, A, Martin-Gomez, MT, Abad, R, Bloise, I, Campins, M, Gonzalez-Praetorius, A, Gutierrez, MN, Martin-Gonzalez, H, Munoz-Almagro, C, Orellana, MA, de Pablos, M, Roca-Grande, J, Rodrigo, C, Rodriguez, ME, Uriona, S, Vidal, MJ, Pumarola, T, Larrosa, MN and Gonzalez-Lopez, JJ
Publicada:
1 may 2022
Resumen:
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(-292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV.
Filiaciones:
Mir-Cros, A:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Moreno-Mingorance, A:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Martin-Gomez, MT:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Abad, R:
Inst Salud Carlos III, Madrid, Spain
Bloise, I:
Hosp Univ La Paz, Madrid, Spain
Campins, M:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Gonzalez-Praetorius, A:
Hosp Univ Guadalajara, Guadalajara, Spain
Gutierrez, MN:
Complejo Asistencial Univ Salamanca, Salamanca, Spain
Martin-Gonzalez, H:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Munoz-Almagro, C:
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
Univ Int Catalunya, Barcelona, Spain
CIBER Epidemiol & Salud Publ, Barcelona, Spain
Orellana, MA:
Hosp Univ 12 Octubre, Madrid, Spain
de Pablos, M:
Hosp Univ La Paz, Madrid, Spain
Roca-Grande, J:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Rodriguez, ME:
Hosp Univ Guadalajara, Guadalajara, Spain
Uriona, S:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Vidal, MJ:
Agencia Salut Publ Catalunya, Barcelona, Spain
Pumarola, T:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
CIBER Enfermedades Infecciosas, Barcelona, Spain
Larrosa, MN:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
CIBER Enfermedades Infecciosas, Barcelona, Spain
Gonzalez-Lopez, JJ:
Hosp Univ Vall dHebron Campus, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
CIBER Enfermedades Infecciosas, Barcelona, Spain
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