Atrial amyloidosis: mechanisms and clinical manifestations
Por:
Vergaro, G, Aimo, A, Rapezzi, C, Castiglione, V, Fabiani, I, Pucci, A, Buda, G, Passino, C, Lupon, J, Bayes-Genis, A, Emdin, M and Braunwald, E
Publicada:
1 nov 2022
Ahead of Print:
1 ago 2022
Resumen:
Cardiac amyloidosis (CA) is now recognized as an important cause of heart failure. Increased wall thickness and diastolic dysfunction of the left ventricle are the most easily detectable manifestations of CA, but amyloid accumulates in all cardiac structures. Involvement of the left and right atria may be due to the haemodynamic effects of ventricular diastolic dysfunction, the effects of amyloid infiltration into the atrial wall, and the cardiotoxic damage of atrial cardiomyocytes by amyloid precursors. Atrial amyloidosis is an early manifestation of CA, and is associated with an increased risk of atrial fibrillation and thromboembolic events. Furthermore, atrial amyloidosis can be found even in the absence of systemic disease and ventricular involvement. This condition is named isolated atrial amyloidosis and is due to a local overproduction of atrial natriuretic peptide. In this review we summarize the evidence on the mechanisms and clinical relevance of atrial amyloidosis.
Filiaciones:
Vergaro, G:
Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, Pisa, Italy
Fdn Toscana Gabriele Monasterio, Piazza Martini della Liberta 33, I-56124 Pisa, Italy
Aimo, A:
Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, Pisa, Italy
Fdn Toscana Gabriele Monasterio, Piazza Martini della Liberta 33, I-56124 Pisa, Italy
Rapezzi, C:
Univ Ferrara, Cardiol Ctr, Ferrara, Italy
GVM Care & Res, Maria Cecilia Hosp, Ravenna, Italy
Castiglione, V:
Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, Pisa, Italy
Fabiani, I:
Fdn Toscana Gabriele Monasterio, Piazza Martini della Liberta 33, I-56124 Pisa, Italy
Pucci, A:
Univ Hosp Pisa, Pisa, Italy
Buda, G:
Univ Hosp Pisa, Pisa, Italy
Passino, C:
Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, Pisa, Italy
Fdn Toscana Gabriele Monasterio, Piazza Martini della Liberta 33, I-56124 Pisa, Italy
:
Hosp Badalona Germans Trias & Pujol, Heart Inst, Badalona, Spain
:
Hosp Badalona Germans Trias & Pujol, Heart Inst, Badalona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Emdin, M:
Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, Pisa, Italy
Fdn Toscana Gabriele Monasterio, Piazza Martini della Liberta 33, I-56124 Pisa, Italy
Braunwald, E:
Brigham & Womens Hosp, Dept Med, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Boston, MA 02115 USA
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