Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation
Por:
Panagides, V, Del Val, D, Abdel-Wahab, M, Mangner, N, Durand, E, Ihlemann, N, Urena, M, Pellegrini, C, Giannini, F, Scislo, P, Huczek, Z, Landt, M, Auffret, V, Sinning, JM, Cheema, AN, Nombela-Franco, L, Chamandi, C, Campelo-Parada, F, Munoz-Garcia, E, Herrmann, HC, Testa, L, Kim, WK, Castillo, JC, Alperi, A, Tchetche, D, Bartorelli, AL, Kapadia, S, Stortecky, S, Amat-Santos, I, Wijeysundera, HC, Lisko, J, Gutierrez-Ibanes, E, Serra, V, Salido, L, Alkhodair, A, Livi, U, Chakravarty, T, Lerakis, S, Vilalta, V, Regueiro, A, Romaguera, R, Kappert, U, Barbanti, M, Masson, JB, Maes, F, Fiorina, C, Miceli, A, Kodali, S, Ribeiro, HB, Mangione, JA, de Brito, FS, Dato, GMA, Rosato, F, Ferreira, MC, de Lima, VC, Colafranceschi, AS, Abizaid, A, Marino, MA, Esteves, V, Andrea, J, Godinho, RR, Alfonso, F, Eltchaninoff, H, Sondergaard, L, Himbert, D, Husser, O, Latib, A, Le Breton, H, Servoz, C, Pascual, I, Siddiqui, S, Olivares, P, Hernandez-Antolin, R, Webb, JG, Sponga, S, Makkar, R, Kini, AS, Boukhris, M, Gervais, P, Linke, A, Crusius, L, Holzhey, D and Rodes-Cabau, J
Publicada:
1 jun 2022
Ahead of Print:
1 may 2022
Resumen:
Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation >= 2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p < 0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p < 0.001) and septic shock (adjusted p < 0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation >= 2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up. (C) 2022 Elsevier Inc. All rights reserved.
Filiaciones:
Panagides, V:
Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada
Del Val, D:
Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada
Abdel-Wahab, M:
Univ Leipzig, Heart Ctr, Leipzig, Germany
Segeberger Kliniken, Heart Ctr, Bad Segeberg, Germany
Mangner, N:
Univ Leipzig, Heart Ctr, Leipzig, Germany
Tech Univ Dresden, Herzzentrum Dresden, Dresden, Germany
Durand, E:
Normandie Univ, Dept Cardiol, UNIROUEN, U1096,CHU Rouen, Rouen, France
Ihlemann, N:
Rigshosp, Copenhagen, Denmark
Urena, M:
Bichat Hop, Paris, France
Pellegrini, C:
Deutsch Herzzentrum Munich, Munich, Germany
Giannini, F:
Osped San Raffaele, Milan, Italy
Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy
Scislo, P:
Med Univ Warsaw, Dept Cardiol, Warsaw, Poland
Huczek, Z:
Med Univ Warsaw, Dept Cardiol, Warsaw, Poland
Landt, M:
Segeberger Kliniken, Heart Ctr, Bad Segeberg, Germany
Auffret, V:
Univ Rennes, INSERM, CHU Rennes, LTSI,UMR1099, Rennes, France
Sinning, JM:
Heart Ctr Bonn, Bonn, Germany
Cheema, AN:
St Michaels Hosp, Toronto, ON, Canada
Southlake Reg Hlth Ctr, Newmarket, ON, Canada
Nombela-Franco, L:
Hosp Clin San Carlos, Cardiovasc Inst, Inst Invest Sanitaria San Carlos, Madrid, Spain
Chamandi, C:
Hop Europeen Georges Pompidou, Paris, France
Campelo-Parada, F:
Hop Rangueil, Toulouse, France
Munoz-Garcia, E:
Hosp Univ Virgen de La Victoria, Malaga, Spain
Herrmann, HC:
Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA
Testa, L:
IRCCS Policlin San Donato, Milan, Italy
Kim, WK:
Kerckhoff Heart & Thorax Ctr, Bad Nauheim, Germany
Castillo, JC:
Hosp Univ Reina Sofia, Cordoba, Spain
Alperi, A:
Hosp Univ Cent Asturias, Oviedo, Spain
Tchetche, D:
Clin Pasteur, Toulouse, France
Bartorelli, AL:
Univ Milan, Ctr Cardiol Monzino, IRCCS, Milan, Italy
Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy
Kapadia, S:
Cleveland Clin, Cleveland, OH 44106 USA
Stortecky, S:
Univ Bern, Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland
Swiss TAVI, Bern, Switzerland
Amat-Santos, I:
Hosp Clin Univ Valladolid, CIBERCV, Valladolid, Spain
Wijeysundera, HC:
Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
Lisko, J:
Emory Univ, Sch Med, Atlanta, GA USA
Gutierrez-Ibanes, E:
Hosp Gregorio Maranon, Inst Invest Univ Gregorio Maranon, Madrid, Spain
Serra, V:
Hosp Valle De Hebron, Barcelona, Spain
Salido, L:
Hosp Univ Ramon y Cajal, Madrid, Spain
Alkhodair, A:
St Pauls Hosp, Vancouver, BC, Canada
Livi, U:
Univ Hosp Udine, Udine, Italy
Chakravarty, T:
Cedars Sinai Heart Inst, Los Angeles, CA USA
Lerakis, S:
Emory Univ, Sch Med, Atlanta, GA USA
Mt Sinai Hosp, New York, NY 10029 USA
:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Regueiro, A:
Hosp Clin Barcelona, Barcelona, Spain
Romaguera, R:
Hosp Bellvitge Princeps Espanya, Lhospitalet De Llobregat, Spain
Kappert, U:
Tech Univ Dresden, Herzzentrum Dresden, Dresden, Germany
Barbanti, M:
Univ Catania, AOU Policlin Vittorio Emanuele, Catania, Italy
Masson, JB:
Ctr Hosp Univ Montreal, Montreal, PQ, Canada
Maes, F:
Clin Univ St Luc, Brussels, Belgium
Fiorina, C:
ASST Spedali Civili Brescia, Brescia, Italy
Miceli, A:
Ist Clin St Ambrogio, Milan, Italy
Univ Hosp Galway, Galway, Ireland
Kodali, S:
Columbia Univ, Med Ctr, New York, NY USA
Ribeiro, HB:
Univ Sao Paulo, Med Sch, Heart Inst, InCor, Sao Paulo, Brazil
Hosp Samaritan Paulista, Sao Paulo, Brazil
Mangione, JA:
Hosp Beneficencia Portuguesa, Sao Paulo, Brazil
de Brito, FS:
Univ Sao Paulo, Med Sch, Heart Inst, InCor, Sao Paulo, Brazil
Dato, GMA:
Osped Mauriziano Umberto 1, Turin, Italy
Rosato, F:
Azienda Osped S Cocre & Carle, Cuneo, Italy
Ferreira, MC:
Hosp Naval Marcilio Dias, Rio De Janeiro, Brazil
de Lima, VC:
Hosp Sao Francisco Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil
Colafranceschi, AS:
Hosp Procardiaco, Rio De Janeiro, Brazil
Abizaid, A:
Univ Sao Paulo, Med Sch, Heart Inst, InCor, Sao Paulo, Brazil
Marino, MA:
Hosp Madre Teresa, Belo Horizonte, MG, Brazil
Esteves, V:
Hosp Sao Luiz, Sao Paulo, Brazil
Andrea, J:
Clin Sao Vicente, Rio De Janeiro, Brazil
Godinho, RR:
Hosp Samaritan Paulista, Sao Paulo, Brazil
Alfonso, F:
Hosp Univ La Princesa, Madrid, Spain
Eltchaninoff, H:
Normandie Univ, Dept Cardiol, UNIROUEN, U1096,CHU Rouen, Rouen, France
Sondergaard, L:
Rigshosp, Copenhagen, Denmark
Himbert, D:
Bichat Hop, Paris, France
Husser, O:
Deutsch Herzzentrum Munich, Munich, Germany
Augustinum Klin Munchen, Munich, Germany
Latib, A:
Osped San Raffaele, Milan, Italy
Montefiore Med Ctr, New York, NY USA
Le Breton, H:
Univ Rennes, INSERM, CHU Rennes, LTSI,UMR1099, Rennes, France
Servoz, C:
Hop Rangueil, Toulouse, France
Pascual, I:
Hosp Univ Cent Asturias, Oviedo, Spain
Siddiqui, S:
Clin Pasteur, Toulouse, France
Olivares, P:
Univ Milan, Ctr Cardiol Monzino, IRCCS, Milan, Italy
Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy
Hernandez-Antolin, R:
Hosp Univ Ramon y Cajal, Madrid, Spain
Webb, JG:
St Pauls Hosp, Vancouver, BC, Canada
Sponga, S:
Univ Hosp Udine, Udine, Italy
Makkar, R:
Cedars Sinai Heart Inst, Los Angeles, CA USA
Kini, AS:
Mt Sinai Hosp, New York, NY 10029 USA
Boukhris, M:
Ctr Hosp Univ Montreal, Montreal, PQ, Canada
Gervais, P:
Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada
Linke, A:
Univ Leipzig, Heart Ctr, Leipzig, Germany
Tech Univ Dresden, Herzzentrum Dresden, Dresden, Germany
Crusius, L:
Univ Leipzig, Heart Ctr, Leipzig, Germany
Tech Univ Dresden, Herzzentrum Dresden, Dresden, Germany
Holzhey, D:
Univ Leipzig, Heart Ctr, Leipzig, Germany
Rodes-Cabau, J:
Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada
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