The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies


Por: Manry, J, Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Michailidis, E, Hoffmann, HH, Eto, S, Garcia-Prat, M, Bizien, L, Parra-Martinez, A, Yang, R, Haljasmagi, L, Migaud, M, Sarekannu, K, Maslovskaja, J, de Prost, N, Tandjaoui-Lambiotte, Y, Luyt, CE, Amador-Borrero, B, Gaudet, A, Poissy, J, Morel, P, Richard, P, Cognasse, F, Troya, J, Trouillet-Assant, S, Belot, A, Saker, K, Garcon, P, Riviere, JG, Lagier, JC, Gentile, S, Rosen, LB, Shaw, E, Morio, T, Tanaka, J, Dalmau, D, Tharaux, PL, Sene, D, Stepanian, A, Megarbane, B, Triantafyllia, V, Fekkar, A, Heath, JR, Franco, JL, Anaya, JM, Sole-Violan, J, Imberti, L, Biondi, A, Bonfanti, P, Castagnoli, R, Delmonte, OM, Zhang, Y, Snow, AL, Holland, SM, Biggs, CM, Moncada-Velez, M, Arias, AA, Lorenzo, L, Boucherit, S, Anglicheau, D, Planas, AM, Haerynck, F, Duvlis, S, Ozcelik, T, Keles, S, Bousfiha, AA, El Bakkouri, J, Ramirez-Santana, C, Paul, S, Pan-Hammarstrom, Q, Hammarstrom, L, Dupont, A, Kurolap, A, Metz, CN, Aiuti, A, Casari, G, Lampasona, V, Ciceri, F, Barreiros, LA, Dominguez-Garrido, E, Vidigal, M, Zatz, M, van de Beek, D, Sahanic, S, Tancevski, I, Stepanovskyy, Y, Boyarchuk, O, Nukui, Y, Tsumura, M, Vidaur, L, Tangye, SG, Burrel, S, Duffy, D, Quintana-Murci, L, Klocperk, A, Kann, NY, Shcherbina, A, Lau, YL, Leung, D, Coulongeat, M, Marlet, J, Koning, R, Reyes, LF, Chauvineau-Grenier, A, Venet, F, Monneret, G, Nussenzweig, MC, Arrestier, R, Boudhabhay, I, Baris-Feldman, H, Hagin, D, Wauters, J, Meyts, I, Dyer, AH, Kennelly, S, Bourkeh, NM, Halwan, R, Sharif-Askar, FS, Dorgham, K, Sallette, J, Sedkaoui, SM, AlKhater, S, Rigo-Bonnin, R, Morandeira, F, Roussel, L, Vinh, DC, Erikstrup, C, Condino-Neto, A, Prando, C, Bondarenko, A, Spaan, AN, Gilardin, L, Fellay, J, Lyonnet, S, Bilguvar, K, Lifton, RP, Mane, S, Anderson, MS, Boisson, B, Beziat, V, Zhang, SY, Andreakos, E, Hermine, O, Pujol, A, Peterson, P, Mogensen, TH, Rowen, L, Mond, J, Debette, S, de Lamballerie, X, Burdet, C, Bouadma, L, Zins, M, Soler-Palacin, P, Colobran, R, Gorochov, G, Solanich, X, Susen, S, Martinez-Picado, J, Raoult, D, Vasse, M, Gregersen, PK, Piemonti, L, Rodriguez-Gallego, C, D Notarangelo, L, Su, HC, Kisand, K, Okada, S, Puel, A, Jouanguy, E, Rice, CM, Tiberghien, P, Zhang, Q, Casanova, JL, Abel, L and Cobat, A

Publicada: 24 may 2022
Resumen:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in similar to 20% of deceased patients across age groups, and in similar to 1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-alpha 2 or IFN-omega, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and >= 70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those >= 80 y old for autoantibodies neutralizing IFN-alpha 2 or IFN-omega, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-alpha 2 and IFN-omega. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.

Filiaciones:
Manry, J:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Bastard, P:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Gervais, A:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Le Voyer, T:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Rosain, J:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Philippot, Q:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Michailidis, E:
 Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA

Hoffmann, HH:
 Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA

Eto, S:
 Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan

Garcia-Prat, M:
 Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

Bizien, L:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Parra-Martinez, A:
 Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

Yang, R:
 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Haljasmagi, L:
 Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia

Migaud, M:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Sarekannu, K:
 Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia

Maslovskaja, J:
 Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia

de Prost, N:
 Hop Univ Henri Mondor, AP HP, Serv Med Intens Reanimat, F-94010 Creteil, France

 Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin Cardiovasc & Resp Manifestat Acute, F-94010 Creteil, France

Tandjaoui-Lambiotte, Y:
 Avicenne Hosp, AP HP, Hypoxia & Lung, INSERM U1272, F-93022 Bobigny, France

 Ctr Hosp St Denis, Infect Antimicrobials Modelling Evolut, Pneumol & Infectiol INSERM UMR 1137, Hypoxia & Lung INSERM U1272, F-93200 St Denis, France

Luyt, CE:
 Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Med Intens Reanimat, F-75013 Paris, France

 Inst Cardiometab & Nutr, INSERM, UMRS 1166, iCAN, F-75013 Paris, France

Amador-Borrero, B:
 Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France

Gaudet, A:
 Univ Lille, Inst Pasteur Lille, Ctr Infect & Immun Lille, INSERM U1019,CNRS UMR9017, F-59000 Lille, France

 Ctr Hosp Univ Lille, Hop Roger Salengro Lille, Pole Reanimat, F-59000 Lille, France

Poissy, J:
 Univ Lille, Inst Pasteur Lille, Ctr Infect & Immun Lille, INSERM U1019,CNRS UMR9017, F-59000 Lille, France

 Ctr Hosp Univ Lille, Hop Roger Salengro Lille, Pole Reanimat, F-59000 Lille, France

Morel, P:
 Etab Francais Sang, F-93218 La Plaine St Denis, France

 Univ Franche Comte, Interact Hote Greffon Tumeur & Ingn Cellulaire &, INSERM, Etab Francais Sang, F-25000 Besancon, France

Richard, P:
 Etab Francais Sang, F-93218 La Plaine St Denis, France

Cognasse, F:
 Univ Jean Monnet St Etienne, Univ Lyon, Sante Ingn Biol St Etienne SAINBIOSE, INSERM U1059, F-42000 St Etienne, France

 Etab Francais Sang, Auvergne Rhone Alpes, F-42000 St Etienne, France

Troya, J:
 Infanta Leonor Univ Hosp, Dept Internal Med, Madrid 28031, Spain

 Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria 35450, Spain

Trouillet-Assant, S:
 Hosp Civils Lyon, F-69002 Lyon, France

 Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France

 Lyon Sud Hosp, Hosp Civils Lyon, Hosp Civils Lyon BioMerieux, Joint Res Unit, F-69495 Pierre Benite, France

Belot, A:
 Hosp Civils Lyon, F-69002 Lyon, France

 Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France

 Natl Referee Ctr Rheumat & Autoimmune & System Di, F-69000 Lyon, France

 Hosp Civils Lyon, Immunopathol Federat Lyon Immunopathol Federat LI, F-69002 Lyon, France

Saker, K:
 Hosp Civils Lyon, F-69002 Lyon, France

 Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France

Garcon, P:
 Grand Hop Est Francilien Site Marne La Vallee, Intens Care Unit, F-77600 Jossigny, France

Riviere, JG:
 Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

Lagier, JC:
 Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Microbes Evolut Phylogenie & Infect MEPHI,Inst Re, F-13005 Marseille, France

Gentile, S:
 Hop Univ Marseille, AP HP, Serv Evaluat Me, F-13005 Marseille, France

 Aix Marseille Univ, Ctr Etud & Rech Serv Sante & Qualite Vie CEReSS, Hlth Serv Res & Qual Life Ctr, Sch Med,EA 3279, F-13385 Marseille, France

Rosen, LB:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

Shaw, E:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

Morio, T:
 Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo 1138510, Japan

Tanaka, J:
 Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Epidemiol Infect Dis Control & Prevent, Hiroshima 7348553, Japan

Dalmau, D:
 Univ Barcelona, Hosp Univ MutuaTerrassa, Barcelona 08193, Spain

 Fundacio Docencia & Recerca Mutua Terrassa, Terrassa 08221, Spain

Tharaux, PL:
 Univ Paris, Paris Cardiovasc Res Ctr PARCC, INSERM, F-75015 Paris, France

Sene, D:
 Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France

Stepanian, A:
 Univ Paris, Hop Lariboisiere, AP HP, Serv Hematol Biol, F-75010 Paris, France

 Univ Paris, Inst Univ Hematol, EA3518, Hop St Louis, F-75010 Paris, France

Megarbane, B:
 Univ Paris, Hop Lariboisiere, AP HP, Reanimat Med & Toxicol,INSERM,UMRS 1144, F-75010 Paris, France

Triantafyllia, V:
 Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Immunobiol Lab, Athens 11527, Greece

Fekkar, A:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Grp Hosp Pitie Salpetriere, AP HP, Serv Parasitol Mycol, F-75013 Paris, France

Heath, JR:
 Inst Syst Biol, Seattle, WA 98109 USA

Franco, JL:
 Univ Antioquia UdeA, Sch Med, Dept Microbiol & Parasitol, Primary Immunodeficiencies Grp, Medellin 050010, Colombia

Anaya, JM:
 Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota 110111, Colombia

 Natl Acad Med Colombia, Bogota 110231, Colombia

Sole-Violan, J:
 Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Intens Care Med, Las Palmas Gran Canaria 35010, Spain

 Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Enfermedades Resp, Madrid 28029, Spain

Imberti, L:
 Spedali Civili Brescia, Diagnost Dept, CHematooncol Res Lab Assoc Italiana Contro Leucem, Azienda Socio Sanit Terr, I-25123 Brescia, Italy

Biondi, A:
 Univ Milano Bicocca, Fdn Monza Brianza Bambino Mamma MBBM, European Reference Network Rare Hereditary Metab, Pediat Dept,EuroBloodNet,Osped San Gerardo, I-20900 Monza, Italy

 Univ Milano Bicocca, Fdn Monza Brianza Bambino Mamma MBBM, European Reference Network Rare Hereditary Metab, EuroBloodNet,San Gerardo Hosp,Ctr TettamantiEurop, I-20900 Monza, Italy

Bonfanti, P:
 Univ Milano Bicocca, San Gerardo Hosp, Dept Infect Dis, I-20900 Monza, Italy

Castagnoli, R:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

 Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Pediat Clin,Policlin San Matteo, I-27100 Pavia, Italy

Delmonte, OM:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

Zhang, Y:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

 NIAID, Clin Genom Program, NIH, Bethesda, MD 20892 USA

Snow, AL:
 Uniformed Serv Univ Hlth Sci, Dept Pharmacol & Mol Therapeut, Bethesda, MD 20814 USA

Holland, SM:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

Biggs, CM:
 Univ British Columbia, British Columbia Children s Hosp, Dept Pediat, Vancouver, BC V6H 0B3, Canada

Moncada-Velez, M:
 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Arias, AA:
 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

 Univ Antioquia UdeA, Primary Immunodeficiencies Grp, Medellin 050010, Colombia

 Univ Antioquia UdeA, Sch Microbiol, Medellin 050010, Colombia

Lorenzo, L:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Boucherit, S:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

Anglicheau, D:
 Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, F-75743 Paris, France

 Univ Paris, Inst Necker Enfants Malades, INSERM U1151, CNRS UMR 8253, F-75015 Paris, France

Planas, AM:
 Spanish Natl Res Council, Inst Biomed Res, Barcelona 08036, Spain

 Inst Invest Biomed August Pi & Sunyer, Barcelona 08036, Spain

Haerynck, F:
 Ghent Univ Hosp, Dept Paediat Immunol & Pulmonol, Ctr Primary Immunodeficiency Ghent, Jeffrey Modell Diag & Res Ctr, B-9000 Ghent, Belgium

Duvlis, S:
 Univ Goce Delchev, Fac Med Sci, Stip 2000, North Macedonia

 Republ North Macedonia, Inst Publ Hlth, Skopje 1000, North Macedonia

Ozcelik, T:
 Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey

Keles, S:
 Necmettin Erbakan Univ, Meram Fac Med, TR-42080 Konya, Turkey

Bousfiha, AA:
 Ctr Hosp Univ Ibn Roucshd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca 20360, Morocco

 Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie LICIA, Casablanca 20250, Morocco

El Bakkouri, J:
 Ctr Hosp Univ Ibn Roucshd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca 20360, Morocco

 Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie LICIA, Casablanca 20250, Morocco

Ramirez-Santana, C:
 Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota 111211, Colombia

Paul, S:
 Univ Hosp St Etienne, Grp Immunit Muqueuses & Agents Pathogenes GIMAP, Ctr Int Rech Infectiol, Dept Immunol,CIC1408,INSERM U1111, F-42000 St Etienne, France

Pan-Hammarstrom, Q:
 Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden

Hammarstrom, L:
 Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden

Dupont, A:
 Univ Lille, Ctr Hosp Univ Lille, European Genom Inst Diabet EGID, INSERM,Inst Pasteur Lille,U1011, F-59000 Lille, France

Kurolap, A:
 Tel Aviv Sourasky Med Ctr, Genet Inst & Genom Ctr, IL-6423906 Tel Aviv, Israel

Metz, CN:
 Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA

Aiuti, A:
 Univ Vita Salute San Raffaele, I-20132 Milan, Italy

 Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Clin Genom, I-20132 Milan, Italy

Casari, G:
 Univ Vita Salute San Raffaele, I-20132 Milan, Italy

 Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Clin Genom, I-20132 Milan, Italy

Lampasona, V:
 Ist Ricovero Cura Carattere Sci IRCCS San Raffael, Diab Res Inst, I-20132 Milan, Italy

Ciceri, F:
 Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy

Barreiros, LA:
 Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508060 Sao Paulo, Brazil

Dominguez-Garrido, E:
 Ctr Invest Biomed La Rioja, Fdn Rioja Salud, Logrono 26006, Spain

Vidigal, M:
 Univ Sao Paulo, BR-05508060 Sao Paulo, Brazil

Zatz, M:
 Univ Sao Paulo, BR-05508060 Sao Paulo, Brazil

van de Beek, D:
 Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

Sahanic, S:
 Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria

Tancevski, I:
 Shupyk Natl Healthcare Univ Ukraine, UA-04112 Kiev, Ukraine

Stepanovskyy, Y:
 I Horbachevsky Ternopil Natl Med Univ, Dept Childrens Dis & Pediat Surg, UA-46022 Ternopol, Ukraine

Boyarchuk, O:
 Tokyo Med & Dent Univ, Hosp Med, Dept Infect Control & Prevent, Tokyo 1138655, Japan

Nukui, Y:
 Tokyo Med & Dent Univ, Hosp Med, Dept Infect Control & Prevent, Tokyo 1138655, Japan

Tsumura, M:
 Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan

Vidaur, L:
 Donostia Univ Hosp, Biodonostia Inst Donostia, Intens Care Med, San Sebastian 20014, Spain

 Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Enfermedes Resp, Madrid 28029, Spain

Tangye, SG:
 Garvan Inst Med Res, Sydney, NSW 2010, Australia

 Univ New South Wales, Fac Med & Hlth, ISt Vincents Clin Sch, Sydney, NSW, Australia

Burrel, S:
 Sorbonne Univ, Hop Pitie Salpeetriere, AP HP,Serv Virol, INSERM U1136,Inst Pierre Louis Epidemiol & Sante, F-75013 Paris, France

Duffy, D:
 Univ Paris Cite, Inst Pasteur, Translat Immunol Unit, F-75015 Paris, France

Quintana-Murci, L:
 Inst Pasteur, CNRS UMR 2000, Human Evolutionary Genet Unit, F-75015 Paris, France

 Coll France, Dept Human Genom & Evolut, F-75231 Paris, France

Klocperk, A:
 Charles Univ Prague, Dept Immunol, Fac Med 2, Prague 15006, Czech Republic

 Univ Hosp Motol, Prague 15006, Czech Republic

Kann, NY:
 Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Immunol, Moscow 117997, Russia

Shcherbina, A:
 Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Immunol, Moscow 117997, Russia

Lau, YL:
 Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong 999077, Peoples R China

Leung, D:
 Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong 999077, Peoples R China

Coulongeat, M:
 Tours Univ, Div Geriatr Med, Med Ctr, F-37044 Tours, France

Marlet, J:
 Univ Tours, INSERM U1259, Morphogenese & Antigenicite VIH & Virus Hepatit M, F-37044 Tours, France

 Ctr Hosp Univ Tours, Serv Bacteriol Virol & Hyg Hosp, F-37044 Tours, France

Koning, R:
 Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

Reyes, LF:
 Univ La Sabana, Dept Microbiol, Chia 250001, Colombia

 Clin Univ La Sabana, Dept Crit Care Med, Chia 250001, Colombia

Chauvineau-Grenier, A:
 Hosp Intercommunal Robert Ballanger, Serv Biol Med, F-93600 Aulnay Sous Bois, France

Venet, F:
 Hop Edouard Herriot, Hosp Civils Lyon, Lab Immunol, F-69437 Lyon, France

 Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, Ecole Normale Super Lyon, INSERM U1111,CNRS,UMR5308, F-69007 Lyon, France

 Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Pathophysiol Injury Induced Immunosuppress, EA 7426,BioMerieux,Hop Edouard Herriot, F-69437 Lyon, France

Monneret, G:
 Hop Edouard Herriot, Hosp Civils Lyon, Lab Immunol, F-69437 Lyon, France

 Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Pathophysiol Injury Induced Immunosuppress, EA 7426,BioMerieux,Hop Edouard Herriot, F-69437 Lyon, France

Nussenzweig, MC:
 Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

 Rockefeller Univ, HHMI, New York, NY 10065 USA

Arrestier, R:
 Hop Univ Henri Mondor, AP HP, Serv Med Intens Reanimat, F-94010 Creteil, France

 Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin Cardiovasc & Resp Manifestat Acute, F-94010 Creteil, France

Boudhabhay, I:
 Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, F-75743 Paris, France

 Univ Paris, Inst Necker Enfants Malades, INSERM U1151, CNRS UMR 8253, F-75015 Paris, France

Baris-Feldman, H:
 Tel Aviv Sourasky Med Ctr, Genet Inst & Genom Ctr, IL-6423906 Tel Aviv, Israel

 Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel

Hagin, D:
 Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel

 Tel Aviv Sourasky Med Ctr, Dept Med, Allergy & Clin Immunol Unit, IL-6423906 Tel Aviv, Israel

Wauters, J:
 Univ Hosp Leuven, Med Intens Care Unit, B-3000 Leuven, Belgium

Meyts, I:
 Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Inborn Errors Immun, B-3000 Leuven, Belgium

 Univ Hosp Leuven, Dept Pediat, Jeffrey Modell Diagnost & Res Network Ctr, B-3000 Leuven, Belgium

Dyer, AH:
 Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin D24 NR0A, Ireland

 Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland

Kennelly, S:
 Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin D24 NR0A, Ireland

 Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland

Bourkeh, NM:
 Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland

Halwan, R:
 Univ Sharjah, Sharjah Inst Med Res, Coll Med, Sharjah 27272, U Arab Emirates

 King Saud Univ, Coll Med, Immunol Res Lab, Riyadh 11362, Saudi Arabia

Sharif-Askar, FS:
 Univ Sharjah, Sharjah Inst Med Res, Coll Med, Sharjah 27272, U Arab Emirates

Dorgham, K:
 Sorbonne Univ, Ctr Immunol & Malad Infect, INSERM, F-75013 Paris, France

Sallette, J:
 Cerba HealthCare, F-92130 Issy Les Moulineaux, France

Sedkaoui, SM:
 Cerba HealthCare, F-92130 Issy Les Moulineaux, France

AlKhater, S:
 King Fahad Hosp Univ, Dept Pediat, Al Khobar 34445, Saudi Arabia

 Imam Abdulrahman Bin Faisal Univ, Coll Med, Dammam 34212, Saudi Arabia

Rigo-Bonnin, R:
 Bellvitge Biomed Res Inst IDIBELL, Hosp Univ Bellvitge, Dept Clin Lab, Barcelona 08908, Spain

Morandeira, F:
 Bellvitge Biomed Res Inst IDIBELL, Hosp Univ Bellvitge, Dept Immunol, Barcelona 08908, Spain

Roussel, L:
 McGill Univ Hlth Ctr, Div Infect Dis, Dept Med, Montreal, PQ H4A 3J1, Canada

 McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ H4A 3J1, Canada

Vinh, DC:
 McGill Univ Hlth Ctr, Div Infect Dis, Dept Med, Montreal, PQ H4A 3J1, Canada

 McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ H4A 3J1, Canada

Erikstrup, C:
 Aarhus Univ Hosp, Dept Clin Immunol, DK-8000 Aarhus, Denmark

Condino-Neto, A:
 Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508060 Sao Paulo, Brazil

Prando, C:
 Inst Pesquisa Pele Pequeno Principe, Fac Pequeno Principe, BR-80250200 Curitiba, Parana, Brazil

Bondarenko, A:
 Shupyk Natl Healthcare Univ Ukraine, UA-04112 Kiev, Ukraine

Spaan, AN:
 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

 Univ Med Ctr Utrecht, Dept Med Microbiol, NL-3584 CX Utrecht, Netherlands

Gilardin, L:
 Hop Univ Jean Verdier, AP HP, Serv Med Interne, F-93140 Bondy, France

 Ctr Rech Cordeliers, INSERM U1138, F-75006 Paris, France

Fellay, J:
 Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland

 Lausanne Univ Hosp, Precis Med Unit, CH-1011 Lausanne, Switzerland

 Univ Lausanne, CH-1011 Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

Lyonnet, S:
 Univ Paris, Imagine Inst, INSERM, UMR 1163, F-75015 Paris, France

Bilguvar, K:
 Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT 06511 USA

 Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

 Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA

 Acibadem Univ, Dept Med Genet, Sch Med, TR-34750 Istanbul, Turkey

Lifton, RP:
 Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT 06511 USA

 Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

 Rockefeller Univ, Lab Human Genet & Genom, New York, NY 10065 USA

Mane, S:
 Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

Anderson, MS:
 Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

Boisson, B:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Beziat, V:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Zhang, SY:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Andreakos, E:
 Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Immunobiol Lab, Athens 11527, Greece

Hermine, O:
 Univ Paris, Imagine Inst, F-75015 Paris, France

 Hop Necker Enfants Malad, AP HP, Dept Hematol, F-75015 Paris, France

Pujol, A:
 Bellvitge Biomed Res Inst IDIBELL, Neurometabol Dis Lab, Barcelona 08908, Spain

 Inst Salud Carlos III, Ctr Biomed Res Rare Dis CIBERER U759, Madrid 28029, Spain

 Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

Peterson, P:
 Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia

Mogensen, TH:
 Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark

 Aarhus Univ, Dept Biomed, DK-8000 Aarhus, Denmark

Rowen, L:
 Inst Syst Biol, Seattle, WA 98109 USA

Mond, J:
 ADMA Biol Inc, Ramsey, NJ 07446 USA

Debette, S:
 Univ Bordeaux, Bordeaux Populat Hlth Ctr, INSERM, UMR1219, F-33000 Bordeaux, France

 Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, F-33000 Bordeaux, France

de Lamballerie, X:
 Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, Inst Rech & Dev IRD 190, Unit Virus Mergents,INSERM 1207, F-13005 Marseille, France

Burdet, C:
 Hop Bichat Claude Bernard, Epidemiol Clin Ctr Invest Clin CIC EP, INSERM CIC 1425, F-75018 Paris, France

 Univ Paris, Infect Antimicrobials Modelling Evolut IAME, UMR 1137, INSERM, F-75870 Paris, France

 Hop Bichat Claude Bernard, AP HP, Dept Epidemiol Biostat & Rech Clin, F-75018 Paris, France

Bouadma, L:
 Univ Paris, Infect Antimicrobials Modelling Evolut IAME, UMR 1137, INSERM, F-75870 Paris, France

 Nord Univ Paris, Hop Bichat, AP HP, Serv Reanimat Med & Malad Infect, F-75018 Paris, France

Zins, M:
 Univ Paris, Cohorte Constances Grp Hosp Univ Ctr, AP HP, F-94800 Villejuif, France

Soler-Palacin, P:
 Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

Colobran, R:
 Univ Autonoma Barcelona, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Div Immunol,Genet Dept, Barcelona 08035, Spain

Gorochov, G:
 Sorbonne Univ, Ctr Immunol & Malad Infect, INSERM, F-75013 Paris, France

 Hop La Pitie Salpetriere, AP HP, Dept Immunol, F-75015 Paris, France

Solanich, X:
 Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Internal Med, Barcelona 08908, Spain

Susen, S:
 Univ Lille, Ctr Hosp Univ Lille, European Genom Inst Diabet EGID, INSERM,Inst Pasteur Lille,U1011, F-59000 Lille, France

:
 Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

 IrsiCaixa AIDS Res Inst, Badalona 08916, Spain

 Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona 08916, Spain

 Univ Catalonia, Univ Vic Cent, Dept Infect Dis & Immun, Vic 08500, Spain

 Inst Salud Carlos III, Consorcio Ctr Invest Biomed Red Enfermedades Infe, Madrid 28029, Spain

Raoult, D:
 Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Microbes Evolut Phylogenie & Infect MEPHI,Inst Re, F-13005 Marseille, France

Vasse, M:
 Hop Foch, Serv Biol Clin, F-92150 Suresnes, France

 Hop Foch, UMR S 1176, F-92150 Suresnes, France

Gregersen, PK:
 Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA

Piemonti, L:
 Ist Ricovero Cura Carattere Sci IRCCS San Raffael, Diab Res Inst, I-20132 Milan, Italy

Rodriguez-Gallego, C:
 Univ Hosp Gran Canaria Dr Negrin, Dept Immunol, Canarian Hlth Syst, Las Palmas Gran Canaria 35010, Spain

D Notarangelo, L:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

Su, HC:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Kisand, K:
 Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia

Okada, S:
 Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan

Puel, A:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Jouanguy, E:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Rice, CM:
 Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA

Tiberghien, P:
 Etab Francais Sang, F-93218 La Plaine St Denis, France

 Univ Franche Comte, Interact Hote Greffon Tumeur & Ingn Cellulaire &, INSERM, Etab Francais Sang, F-25000 Besancon, France

Zhang, Q:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Casanova, JL:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

 Rockefeller Univ, HHMI, New York, NY 10065 USA

Abel, L:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

Cobat, A:
 Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France

 Univ Paris, Imagine Inst, F-75015 Paris, France

 Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
ISSN: 00278424





Proceedings of the National Academy of Sciences of the United States of America
Editorial
National Academy of Sciences, 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 119 Número: 21
Páginas:
WOS Id: 000841027100010
ID de PubMed: 35576468
imagen Green Submitted, Green Accepted, Green Published, hybrid

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