The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Por:
Manry, J, Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Michailidis, E, Hoffmann, HH, Eto, S, Garcia-Prat, M, Bizien, L, Parra-Martinez, A, Yang, R, Haljasmagi, L, Migaud, M, Sarekannu, K, Maslovskaja, J, de Prost, N, Tandjaoui-Lambiotte, Y, Luyt, CE, Amador-Borrero, B, Gaudet, A, Poissy, J, Morel, P, Richard, P, Cognasse, F, Troya, J, Trouillet-Assant, S, Belot, A, Saker, K, Garcon, P, Riviere, JG, Lagier, JC, Gentile, S, Rosen, LB, Shaw, E, Morio, T, Tanaka, J, Dalmau, D, Tharaux, PL, Sene, D, Stepanian, A, Megarbane, B, Triantafyllia, V, Fekkar, A, Heath, JR, Franco, JL, Anaya, JM, Sole-Violan, J, Imberti, L, Biondi, A, Bonfanti, P, Castagnoli, R, Delmonte, OM, Zhang, Y, Snow, AL, Holland, SM, Biggs, CM, Moncada-Velez, M, Arias, AA, Lorenzo, L, Boucherit, S, Anglicheau, D, Planas, AM, Haerynck, F, Duvlis, S, Ozcelik, T, Keles, S, Bousfiha, AA, El Bakkouri, J, Ramirez-Santana, C, Paul, S, Pan-Hammarstrom, Q, Hammarstrom, L, Dupont, A, Kurolap, A, Metz, CN, Aiuti, A, Casari, G, Lampasona, V, Ciceri, F, Barreiros, LA, Dominguez-Garrido, E, Vidigal, M, Zatz, M, van de Beek, D, Sahanic, S, Tancevski, I, Stepanovskyy, Y, Boyarchuk, O, Nukui, Y, Tsumura, M, Vidaur, L, Tangye, SG, Burrel, S, Duffy, D, Quintana-Murci, L, Klocperk, A, Kann, NY, Shcherbina, A, Lau, YL, Leung, D, Coulongeat, M, Marlet, J, Koning, R, Reyes, LF, Chauvineau-Grenier, A, Venet, F, Monneret, G, Nussenzweig, MC, Arrestier, R, Boudhabhay, I, Baris-Feldman, H, Hagin, D, Wauters, J, Meyts, I, Dyer, AH, Kennelly, S, Bourkeh, NM, Halwan, R, Sharif-Askar, FS, Dorgham, K, Sallette, J, Sedkaoui, SM, AlKhater, S, Rigo-Bonnin, R, Morandeira, F, Roussel, L, Vinh, DC, Erikstrup, C, Condino-Neto, A, Prando, C, Bondarenko, A, Spaan, AN, Gilardin, L, Fellay, J, Lyonnet, S, Bilguvar, K, Lifton, RP, Mane, S, Anderson, MS, Boisson, B, Beziat, V, Zhang, SY, Andreakos, E, Hermine, O, Pujol, A, Peterson, P, Mogensen, TH, Rowen, L, Mond, J, Debette, S, de Lamballerie, X, Burdet, C, Bouadma, L, Zins, M, Soler-Palacin, P, Colobran, R, Gorochov, G, Solanich, X, Susen, S, Martinez-Picado, J, Raoult, D, Vasse, M, Gregersen, PK, Piemonti, L, Rodriguez-Gallego, C, D Notarangelo, L, Su, HC, Kisand, K, Okada, S, Puel, A, Jouanguy, E, Rice, CM, Tiberghien, P, Zhang, Q, Casanova, JL, Abel, L and Cobat, A
Publicada:
24 may 2022
Resumen:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in similar to 20% of deceased patients across age groups, and in similar to 1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-alpha 2 or IFN-omega, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and >= 70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those >= 80 y old for autoantibodies neutralizing IFN-alpha 2 or IFN-omega, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-alpha 2 and IFN-omega. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
Filiaciones:
Manry, J:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Bastard, P:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Gervais, A:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Le Voyer, T:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rosain, J:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Philippot, Q:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Michailidis, E:
Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA
Hoffmann, HH:
Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA
Eto, S:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan
Garcia-Prat, M:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain
Bizien, L:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Parra-Martinez, A:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain
Yang, R:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Haljasmagi, L:
Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia
Migaud, M:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Sarekannu, K:
Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia
Maslovskaja, J:
Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia
de Prost, N:
Hop Univ Henri Mondor, AP HP, Serv Med Intens Reanimat, F-94010 Creteil, France
Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin Cardiovasc & Resp Manifestat Acute, F-94010 Creteil, France
Tandjaoui-Lambiotte, Y:
Avicenne Hosp, AP HP, Hypoxia & Lung, INSERM U1272, F-93022 Bobigny, France
Ctr Hosp St Denis, Infect Antimicrobials Modelling Evolut, Pneumol & Infectiol INSERM UMR 1137, Hypoxia & Lung INSERM U1272, F-93200 St Denis, France
Luyt, CE:
Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Med Intens Reanimat, F-75013 Paris, France
Inst Cardiometab & Nutr, INSERM, UMRS 1166, iCAN, F-75013 Paris, France
Amador-Borrero, B:
Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Gaudet, A:
Univ Lille, Inst Pasteur Lille, Ctr Infect & Immun Lille, INSERM U1019,CNRS UMR9017, F-59000 Lille, France
Ctr Hosp Univ Lille, Hop Roger Salengro Lille, Pole Reanimat, F-59000 Lille, France
Poissy, J:
Univ Lille, Inst Pasteur Lille, Ctr Infect & Immun Lille, INSERM U1019,CNRS UMR9017, F-59000 Lille, France
Ctr Hosp Univ Lille, Hop Roger Salengro Lille, Pole Reanimat, F-59000 Lille, France
Morel, P:
Etab Francais Sang, F-93218 La Plaine St Denis, France
Univ Franche Comte, Interact Hote Greffon Tumeur & Ingn Cellulaire &, INSERM, Etab Francais Sang, F-25000 Besancon, France
Richard, P:
Etab Francais Sang, F-93218 La Plaine St Denis, France
Cognasse, F:
Univ Jean Monnet St Etienne, Univ Lyon, Sante Ingn Biol St Etienne SAINBIOSE, INSERM U1059, F-42000 St Etienne, France
Etab Francais Sang, Auvergne Rhone Alpes, F-42000 St Etienne, France
Troya, J:
Infanta Leonor Univ Hosp, Dept Internal Med, Madrid 28031, Spain
Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria 35450, Spain
Trouillet-Assant, S:
Hosp Civils Lyon, F-69002 Lyon, France
Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France
Lyon Sud Hosp, Hosp Civils Lyon, Hosp Civils Lyon BioMerieux, Joint Res Unit, F-69495 Pierre Benite, France
Belot, A:
Hosp Civils Lyon, F-69002 Lyon, France
Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France
Natl Referee Ctr Rheumat & Autoimmune & System Di, F-69000 Lyon, France
Hosp Civils Lyon, Immunopathol Federat Lyon Immunopathol Federat LI, F-69002 Lyon, France
Saker, K:
Hosp Civils Lyon, F-69002 Lyon, France
Univ Claude Bernard Lyon 1 UCBL, Lyon Univ, Int Ctr Res Infectiol, INSERM U1111,CNRS UMR 5308,ENS,Ecole Natl Super, F-69365 Lyon, France
Garcon, P:
Grand Hop Est Francilien Site Marne La Vallee, Intens Care Unit, F-77600 Jossigny, France
Riviere, JG:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain
Lagier, JC:
Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Microbes Evolut Phylogenie & Infect MEPHI,Inst Re, F-13005 Marseille, France
Gentile, S:
Hop Univ Marseille, AP HP, Serv Evaluat Me, F-13005 Marseille, France
Aix Marseille Univ, Ctr Etud & Rech Serv Sante & Qualite Vie CEReSS, Hlth Serv Res & Qual Life Ctr, Sch Med,EA 3279, F-13385 Marseille, France
Rosen, LB:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Shaw, E:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Morio, T:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo 1138510, Japan
Tanaka, J:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Epidemiol Infect Dis Control & Prevent, Hiroshima 7348553, Japan
Dalmau, D:
Univ Barcelona, Hosp Univ MutuaTerrassa, Barcelona 08193, Spain
Fundacio Docencia & Recerca Mutua Terrassa, Terrassa 08221, Spain
Tharaux, PL:
Univ Paris, Paris Cardiovasc Res Ctr PARCC, INSERM, F-75015 Paris, France
Sene, D:
Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Stepanian, A:
Univ Paris, Hop Lariboisiere, AP HP, Serv Hematol Biol, F-75010 Paris, France
Univ Paris, Inst Univ Hematol, EA3518, Hop St Louis, F-75010 Paris, France
Megarbane, B:
Univ Paris, Hop Lariboisiere, AP HP, Reanimat Med & Toxicol,INSERM,UMRS 1144, F-75010 Paris, France
Triantafyllia, V:
Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Immunobiol Lab, Athens 11527, Greece
Fekkar, A:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Serv Parasitol Mycol, F-75013 Paris, France
Heath, JR:
Inst Syst Biol, Seattle, WA 98109 USA
Franco, JL:
Univ Antioquia UdeA, Sch Med, Dept Microbiol & Parasitol, Primary Immunodeficiencies Grp, Medellin 050010, Colombia
Anaya, JM:
Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota 110111, Colombia
Natl Acad Med Colombia, Bogota 110231, Colombia
Sole-Violan, J:
Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Intens Care Med, Las Palmas Gran Canaria 35010, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Enfermedades Resp, Madrid 28029, Spain
Imberti, L:
Spedali Civili Brescia, Diagnost Dept, CHematooncol Res Lab Assoc Italiana Contro Leucem, Azienda Socio Sanit Terr, I-25123 Brescia, Italy
Biondi, A:
Univ Milano Bicocca, Fdn Monza Brianza Bambino Mamma MBBM, European Reference Network Rare Hereditary Metab, Pediat Dept,EuroBloodNet,Osped San Gerardo, I-20900 Monza, Italy
Univ Milano Bicocca, Fdn Monza Brianza Bambino Mamma MBBM, European Reference Network Rare Hereditary Metab, EuroBloodNet,San Gerardo Hosp,Ctr TettamantiEurop, I-20900 Monza, Italy
Bonfanti, P:
Univ Milano Bicocca, San Gerardo Hosp, Dept Infect Dis, I-20900 Monza, Italy
Castagnoli, R:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Pediat Clin,Policlin San Matteo, I-27100 Pavia, Italy
Delmonte, OM:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Zhang, Y:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
NIAID, Clin Genom Program, NIH, Bethesda, MD 20892 USA
Snow, AL:
Uniformed Serv Univ Hlth Sci, Dept Pharmacol & Mol Therapeut, Bethesda, MD 20814 USA
Holland, SM:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Biggs, CM:
Univ British Columbia, British Columbia Children s Hosp, Dept Pediat, Vancouver, BC V6H 0B3, Canada
Moncada-Velez, M:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Arias, AA:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Univ Antioquia UdeA, Primary Immunodeficiencies Grp, Medellin 050010, Colombia
Univ Antioquia UdeA, Sch Microbiol, Medellin 050010, Colombia
Lorenzo, L:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Boucherit, S:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Anglicheau, D:
Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, F-75743 Paris, France
Univ Paris, Inst Necker Enfants Malades, INSERM U1151, CNRS UMR 8253, F-75015 Paris, France
Planas, AM:
Spanish Natl Res Council, Inst Biomed Res, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer, Barcelona 08036, Spain
Haerynck, F:
Ghent Univ Hosp, Dept Paediat Immunol & Pulmonol, Ctr Primary Immunodeficiency Ghent, Jeffrey Modell Diag & Res Ctr, B-9000 Ghent, Belgium
Duvlis, S:
Univ Goce Delchev, Fac Med Sci, Stip 2000, North Macedonia
Republ North Macedonia, Inst Publ Hlth, Skopje 1000, North Macedonia
Ozcelik, T:
Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
Keles, S:
Necmettin Erbakan Univ, Meram Fac Med, TR-42080 Konya, Turkey
Bousfiha, AA:
Ctr Hosp Univ Ibn Roucshd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca 20360, Morocco
Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie LICIA, Casablanca 20250, Morocco
El Bakkouri, J:
Ctr Hosp Univ Ibn Roucshd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca 20360, Morocco
Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie LICIA, Casablanca 20250, Morocco
Ramirez-Santana, C:
Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota 111211, Colombia
Paul, S:
Univ Hosp St Etienne, Grp Immunit Muqueuses & Agents Pathogenes GIMAP, Ctr Int Rech Infectiol, Dept Immunol,CIC1408,INSERM U1111, F-42000 St Etienne, France
Pan-Hammarstrom, Q:
Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden
Hammarstrom, L:
Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden
Dupont, A:
Univ Lille, Ctr Hosp Univ Lille, European Genom Inst Diabet EGID, INSERM,Inst Pasteur Lille,U1011, F-59000 Lille, France
Kurolap, A:
Tel Aviv Sourasky Med Ctr, Genet Inst & Genom Ctr, IL-6423906 Tel Aviv, Israel
Metz, CN:
Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA
Aiuti, A:
Univ Vita Salute San Raffaele, I-20132 Milan, Italy
Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Clin Genom, I-20132 Milan, Italy
Casari, G:
Univ Vita Salute San Raffaele, I-20132 Milan, Italy
Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Clin Genom, I-20132 Milan, Italy
Lampasona, V:
Ist Ricovero Cura Carattere Sci IRCCS San Raffael, Diab Res Inst, I-20132 Milan, Italy
Ciceri, F:
Ist Ricovero & Cura Carattere Sci IRCCS Osped San, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy
Barreiros, LA:
Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508060 Sao Paulo, Brazil
Dominguez-Garrido, E:
Ctr Invest Biomed La Rioja, Fdn Rioja Salud, Logrono 26006, Spain
Vidigal, M:
Univ Sao Paulo, BR-05508060 Sao Paulo, Brazil
Zatz, M:
Univ Sao Paulo, BR-05508060 Sao Paulo, Brazil
van de Beek, D:
Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
Sahanic, S:
Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria
Tancevski, I:
Shupyk Natl Healthcare Univ Ukraine, UA-04112 Kiev, Ukraine
Stepanovskyy, Y:
I Horbachevsky Ternopil Natl Med Univ, Dept Childrens Dis & Pediat Surg, UA-46022 Ternopol, Ukraine
Boyarchuk, O:
Tokyo Med & Dent Univ, Hosp Med, Dept Infect Control & Prevent, Tokyo 1138655, Japan
Nukui, Y:
Tokyo Med & Dent Univ, Hosp Med, Dept Infect Control & Prevent, Tokyo 1138655, Japan
Tsumura, M:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan
Vidaur, L:
Donostia Univ Hosp, Biodonostia Inst Donostia, Intens Care Med, San Sebastian 20014, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Enfermedes Resp, Madrid 28029, Spain
Tangye, SG:
Garvan Inst Med Res, Sydney, NSW 2010, Australia
Univ New South Wales, Fac Med & Hlth, ISt Vincents Clin Sch, Sydney, NSW, Australia
Burrel, S:
Sorbonne Univ, Hop Pitie Salpeetriere, AP HP,Serv Virol, INSERM U1136,Inst Pierre Louis Epidemiol & Sante, F-75013 Paris, France
Duffy, D:
Univ Paris Cite, Inst Pasteur, Translat Immunol Unit, F-75015 Paris, France
Quintana-Murci, L:
Inst Pasteur, CNRS UMR 2000, Human Evolutionary Genet Unit, F-75015 Paris, France
Coll France, Dept Human Genom & Evolut, F-75231 Paris, France
Klocperk, A:
Charles Univ Prague, Dept Immunol, Fac Med 2, Prague 15006, Czech Republic
Univ Hosp Motol, Prague 15006, Czech Republic
Kann, NY:
Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Immunol, Moscow 117997, Russia
Shcherbina, A:
Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Dept Immunol, Moscow 117997, Russia
Lau, YL:
Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong 999077, Peoples R China
Leung, D:
Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong 999077, Peoples R China
Coulongeat, M:
Tours Univ, Div Geriatr Med, Med Ctr, F-37044 Tours, France
Marlet, J:
Univ Tours, INSERM U1259, Morphogenese & Antigenicite VIH & Virus Hepatit M, F-37044 Tours, France
Ctr Hosp Univ Tours, Serv Bacteriol Virol & Hyg Hosp, F-37044 Tours, France
Koning, R:
Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
Reyes, LF:
Univ La Sabana, Dept Microbiol, Chia 250001, Colombia
Clin Univ La Sabana, Dept Crit Care Med, Chia 250001, Colombia
Chauvineau-Grenier, A:
Hosp Intercommunal Robert Ballanger, Serv Biol Med, F-93600 Aulnay Sous Bois, France
Venet, F:
Hop Edouard Herriot, Hosp Civils Lyon, Lab Immunol, F-69437 Lyon, France
Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, Ecole Normale Super Lyon, INSERM U1111,CNRS,UMR5308, F-69007 Lyon, France
Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Pathophysiol Injury Induced Immunosuppress, EA 7426,BioMerieux,Hop Edouard Herriot, F-69437 Lyon, France
Monneret, G:
Hop Edouard Herriot, Hosp Civils Lyon, Lab Immunol, F-69437 Lyon, France
Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Pathophysiol Injury Induced Immunosuppress, EA 7426,BioMerieux,Hop Edouard Herriot, F-69437 Lyon, France
Nussenzweig, MC:
Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA
Rockefeller Univ, HHMI, New York, NY 10065 USA
Arrestier, R:
Hop Univ Henri Mondor, AP HP, Serv Med Intens Reanimat, F-94010 Creteil, France
Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin Cardiovasc & Resp Manifestat Acute, F-94010 Creteil, France
Boudhabhay, I:
Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, F-75743 Paris, France
Univ Paris, Inst Necker Enfants Malades, INSERM U1151, CNRS UMR 8253, F-75015 Paris, France
Baris-Feldman, H:
Tel Aviv Sourasky Med Ctr, Genet Inst & Genom Ctr, IL-6423906 Tel Aviv, Israel
Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel
Hagin, D:
Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel
Tel Aviv Sourasky Med Ctr, Dept Med, Allergy & Clin Immunol Unit, IL-6423906 Tel Aviv, Israel
Wauters, J:
Univ Hosp Leuven, Med Intens Care Unit, B-3000 Leuven, Belgium
Meyts, I:
Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Inborn Errors Immun, B-3000 Leuven, Belgium
Univ Hosp Leuven, Dept Pediat, Jeffrey Modell Diagnost & Res Network Ctr, B-3000 Leuven, Belgium
Dyer, AH:
Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin D24 NR0A, Ireland
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland
Kennelly, S:
Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin D24 NR0A, Ireland
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland
Bourkeh, NM:
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin D08 W9RT, Ireland
Halwan, R:
Univ Sharjah, Sharjah Inst Med Res, Coll Med, Sharjah 27272, U Arab Emirates
King Saud Univ, Coll Med, Immunol Res Lab, Riyadh 11362, Saudi Arabia
Sharif-Askar, FS:
Univ Sharjah, Sharjah Inst Med Res, Coll Med, Sharjah 27272, U Arab Emirates
Dorgham, K:
Sorbonne Univ, Ctr Immunol & Malad Infect, INSERM, F-75013 Paris, France
Sallette, J:
Cerba HealthCare, F-92130 Issy Les Moulineaux, France
Sedkaoui, SM:
Cerba HealthCare, F-92130 Issy Les Moulineaux, France
AlKhater, S:
King Fahad Hosp Univ, Dept Pediat, Al Khobar 34445, Saudi Arabia
Imam Abdulrahman Bin Faisal Univ, Coll Med, Dammam 34212, Saudi Arabia
Rigo-Bonnin, R:
Bellvitge Biomed Res Inst IDIBELL, Hosp Univ Bellvitge, Dept Clin Lab, Barcelona 08908, Spain
Morandeira, F:
Bellvitge Biomed Res Inst IDIBELL, Hosp Univ Bellvitge, Dept Immunol, Barcelona 08908, Spain
Roussel, L:
McGill Univ Hlth Ctr, Div Infect Dis, Dept Med, Montreal, PQ H4A 3J1, Canada
McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ H4A 3J1, Canada
Vinh, DC:
McGill Univ Hlth Ctr, Div Infect Dis, Dept Med, Montreal, PQ H4A 3J1, Canada
McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ H4A 3J1, Canada
Erikstrup, C:
Aarhus Univ Hosp, Dept Clin Immunol, DK-8000 Aarhus, Denmark
Condino-Neto, A:
Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508060 Sao Paulo, Brazil
Prando, C:
Inst Pesquisa Pele Pequeno Principe, Fac Pequeno Principe, BR-80250200 Curitiba, Parana, Brazil
Bondarenko, A:
Shupyk Natl Healthcare Univ Ukraine, UA-04112 Kiev, Ukraine
Spaan, AN:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Univ Med Ctr Utrecht, Dept Med Microbiol, NL-3584 CX Utrecht, Netherlands
Gilardin, L:
Hop Univ Jean Verdier, AP HP, Serv Med Interne, F-93140 Bondy, France
Ctr Rech Cordeliers, INSERM U1138, F-75006 Paris, France
Fellay, J:
Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Lausanne Univ Hosp, Precis Med Unit, CH-1011 Lausanne, Switzerland
Univ Lausanne, CH-1011 Lausanne, Switzerland
Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Lyonnet, S:
Univ Paris, Imagine Inst, INSERM, UMR 1163, F-75015 Paris, France
Bilguvar, K:
Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT 06511 USA
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA
Acibadem Univ, Dept Med Genet, Sch Med, TR-34750 Istanbul, Turkey
Lifton, RP:
Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT 06511 USA
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Rockefeller Univ, Lab Human Genet & Genom, New York, NY 10065 USA
Mane, S:
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Anderson, MS:
Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
Boisson, B:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Beziat, V:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Zhang, SY:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Andreakos, E:
Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Immunobiol Lab, Athens 11527, Greece
Hermine, O:
Univ Paris, Imagine Inst, F-75015 Paris, France
Hop Necker Enfants Malad, AP HP, Dept Hematol, F-75015 Paris, France
Pujol, A:
Bellvitge Biomed Res Inst IDIBELL, Neurometabol Dis Lab, Barcelona 08908, Spain
Inst Salud Carlos III, Ctr Biomed Res Rare Dis CIBERER U759, Madrid 28029, Spain
Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain
Peterson, P:
Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia
Mogensen, TH:
Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark
Aarhus Univ, Dept Biomed, DK-8000 Aarhus, Denmark
Rowen, L:
Inst Syst Biol, Seattle, WA 98109 USA
Mond, J:
ADMA Biol Inc, Ramsey, NJ 07446 USA
Debette, S:
Univ Bordeaux, Bordeaux Populat Hlth Ctr, INSERM, UMR1219, F-33000 Bordeaux, France
Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, F-33000 Bordeaux, France
de Lamballerie, X:
Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, Inst Rech & Dev IRD 190, Unit Virus Mergents,INSERM 1207, F-13005 Marseille, France
Burdet, C:
Hop Bichat Claude Bernard, Epidemiol Clin Ctr Invest Clin CIC EP, INSERM CIC 1425, F-75018 Paris, France
Univ Paris, Infect Antimicrobials Modelling Evolut IAME, UMR 1137, INSERM, F-75870 Paris, France
Hop Bichat Claude Bernard, AP HP, Dept Epidemiol Biostat & Rech Clin, F-75018 Paris, France
Bouadma, L:
Univ Paris, Infect Antimicrobials Modelling Evolut IAME, UMR 1137, INSERM, F-75870 Paris, France
Nord Univ Paris, Hop Bichat, AP HP, Serv Reanimat Med & Malad Infect, F-75018 Paris, France
Zins, M:
Univ Paris, Cohorte Constances Grp Hosp Univ Ctr, AP HP, F-94800 Villejuif, France
Soler-Palacin, P:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Pediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain
Colobran, R:
Univ Autonoma Barcelona, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Div Immunol,Genet Dept, Barcelona 08035, Spain
Gorochov, G:
Sorbonne Univ, Ctr Immunol & Malad Infect, INSERM, F-75013 Paris, France
Hop La Pitie Salpetriere, AP HP, Dept Immunol, F-75015 Paris, France
Solanich, X:
Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Internal Med, Barcelona 08908, Spain
Susen, S:
Univ Lille, Ctr Hosp Univ Lille, European Genom Inst Diabet EGID, INSERM,Inst Pasteur Lille,U1011, F-59000 Lille, France
:
Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain
IrsiCaixa AIDS Res Inst, Badalona 08916, Spain
Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona 08916, Spain
Univ Catalonia, Univ Vic Cent, Dept Infect Dis & Immun, Vic 08500, Spain
Inst Salud Carlos III, Consorcio Ctr Invest Biomed Red Enfermedades Infe, Madrid 28029, Spain
Raoult, D:
Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Microbes Evolut Phylogenie & Infect MEPHI,Inst Re, F-13005 Marseille, France
Vasse, M:
Hop Foch, Serv Biol Clin, F-92150 Suresnes, France
Hop Foch, UMR S 1176, F-92150 Suresnes, France
Gregersen, PK:
Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA
Piemonti, L:
Ist Ricovero Cura Carattere Sci IRCCS San Raffael, Diab Res Inst, I-20132 Milan, Italy
Rodriguez-Gallego, C:
Univ Hosp Gran Canaria Dr Negrin, Dept Immunol, Canarian Hlth Syst, Las Palmas Gran Canaria 35010, Spain
D Notarangelo, L:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Su, HC:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Kisand, K:
Univ Tartu, Inst Biomed & Translat Med, EE-50090 Tartu, Estonia
Okada, S:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima 7348553, Japan
Puel, A:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Jouanguy, E:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Rice, CM:
Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA
Tiberghien, P:
Etab Francais Sang, F-93218 La Plaine St Denis, France
Univ Franche Comte, Interact Hote Greffon Tumeur & Ingn Cellulaire &, INSERM, Etab Francais Sang, F-25000 Besancon, France
Zhang, Q:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Casanova, JL:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Rockefeller Univ, HHMI, New York, NY 10065 USA
Abel, L:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Cobat, A:
Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, F-75015 Paris, France
Univ Paris, Imagine Inst, F-75015 Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA
Green Submitted, Green Accepted, Green Published, hybrid
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