The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders
Por:
Leite, CD, Bonafe, GA, Santos, JC, Martinez, CAR, Ortega, MM and Ribeiro, ML
Publicada:
1 abr 2022
Resumen:
Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders.
Filiaciones:
Leite, CD:
Sao Francisco Univ Med Sch, Lab Immunopharmacol & Mol Biol, BR-12916900 Braganca Paulista, SP, Brazil
Sao Francisco Univ Med Sch, Lab Cell & Mol Tumor Biol & Bioact Cpds, BR-12916900 Braganca Paulista, SP, Brazil
Bonafe, GA:
Sao Francisco Univ Med Sch, Lab Cell & Mol Tumor Biol & Bioact Cpds, BR-12916900 Braganca Paulista, SP, Brazil
:
Josep Carreras Leukaemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
Martinez, CAR:
Sao Francisco Univ USF, Dept Surg & Proctol, BR-12916900 Braganca Paulista, SP, Brazil
Ortega, MM:
Sao Francisco Univ Med Sch, Lab Cell & Mol Tumor Biol & Bioact Cpds, BR-12916900 Braganca Paulista, SP, Brazil
:
Sao Francisco Univ Med Sch, Lab Immunopharmacol & Mol Biol, BR-12916900 Braganca Paulista, SP, Brazil
Josep Carreras Leukaemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
gold, Green Published
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