DBP rs7041 and DHCR7 rs3829251 are Linked to CD4(+) Recovery in HIV Patients on Antiretroviral Therapy
Por:
Resino, S, Jimenez-Sousa, MA, Blanco, J, Pacheco, YM, del Romero, J, Peraire, J, Virseda-Berdices, A, Munoz-Gomez, MJ, Galera-Penaranda, C, Garcia-Fraile, LJ, Benito, JM and Rallon, N
Publicada:
18 ene 2022
Resumen:
Background: The lack of the recovery of CD4(+) T-cells (CD4(+) recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4(+) recovery in naive HIV-infected patients who started ART with low baseline CD4(+).Methods: We conducted a retrospective study in 411 naive individuals with plasma HIV load >200 copies/mL and CD4(+) <200 cells/mm(3). During 24 months of follow-up, all patients had plasma HIV load Results: CD4(+) recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4(+) (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4(+) >= P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4(+) recovery (aAMR = 1.25; q-value = 0.008), slope of CD4(+) recovery >= P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4(+) (aAMR = 1.43; q-value = 0.031), increase in CD4(+) >= P75th (aOR = 3.92; q-value = 0.030), slope of CD4(+) recovery (aAMR = 1.40; q-value = 0.036), slope of CD4(+) recovery >= P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 5.68; q-value = 0.015).Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
Filiaciones:
Resino, S:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Majadahonda, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
Jimenez-Sousa, MA:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Majadahonda, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
IrsiCaixa AIDS Res Inst, Virol Inmunol Celular, Badalona, Spain
Pacheco, YM:
Inst Biomed Sevilla IBiS, Lab Inmunol, Seville, Spain
del Romero, J:
Hosp Clin San Carlos, Ctr Sanitario Sandoval, Madrid, Spain
Peraire, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
Hosp Univ Tarragona Joan XXIII, Dept Med Interna, Tarragona, Spain
Virseda-Berdices, A:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Majadahonda, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
Munoz-Gomez, MJ:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Majadahonda, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
Galera-Penaranda, C:
Hosp Univ Virgen Arrixaca, Dept Med Interna, Murcia, Spain
Garcia-Fraile, LJ:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas, Madrid, Spain
Hosp Univ La Princesa, Dept Med Interna, Madrid, Spain
Benito, JM:
Univ Autonoma Madrid IIS FJD, Inst Invest Sanitaria, Lab Invest VIH & Hepatitis Viral, UAM,Fdn Jimenez Diaz, Madrid, Spain
Hosp Univ Rey Juan Carlos, Mostoles, Spain
Rallon, N:
Univ Autonoma Madrid IIS FJD, Inst Invest Sanitaria, Lab Invest VIH & Hepatitis Viral, UAM,Fdn Jimenez Diaz, Madrid, Spain
Hosp Univ Rey Juan Carlos, Mostoles, Spain
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