Accelerated biological aging in COVID-19 patients
Por:
Cao, X, Li, WJ, Wang, T, Ran, DZ, Davalos, V, Planas-Serra, L, Pujol, A, Esteller, M, Wang, XL and Yu, HC
Publicada:
19 abr 2022
Resumen:
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual's chronological age (r > 0.8, p < 0.0001). We also find the increasing acceleration of epigenetic aging and telomere attrition in the sequential blood samples from healthy individuals and infected patients developing non-severe and severe COVID-19. In addition, the longitudinal DNA methylation profiling analysis find that the accumulation of epigenetic aging from COVID-19 syndrome could be partly reversed at late clinic phases in some patients. In conclusion, accelerated epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. In addition, the accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome among survivors.
Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations between epigenetic aging and the risk of SARS-CoV-2 infection and severe disease.
Filiaciones:
Cao, X:
Guizhou Prov Peoples Hosp, Dept Oncol, Guiyang, Guizhou, Peoples R China
Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China
Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China
Li, WJ:
Sun Yat Sen Univ, Affiliated Hosp 3, Dept Pulm & Crit Care Med, Guangzhou, Guangdong, Peoples R China
Wang, T:
Thermo Fisher Sci Inc, Res & Dev, Los Angeles, CA USA
Ran, DZ:
Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA
Chongqing Med Univ, Dept Pharmacol, Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China
:
Josep Carreras Leukaemia Res Inst IJC, Barcelona, Catalonia, Spain
Planas-Serra, L:
Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Lab, Barcelona, Catalonia, Spain
ISCIII, Ctr Biomed Res Rare Dis CIBERER, Madrid, Spain
Pujol, A:
Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Lab, Barcelona, Catalonia, Spain
ISCIII, Ctr Biomed Res Rare Dis CIBERER, Madrid, Spain
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain
:
Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Catalonia, Spain
Josep Carreras Leukaemia Res Inst IJC, Barcelona, Catalonia, Spain
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain
Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
Wang, XL:
Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China
Yu, HC:
Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China
Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China
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