Non-small-cell lung cancer
Por:
Gridelli, C, Rossi, A, Carbone, DP, Guarize, J, Karachaliou, N, Mok, T, Petrella, F, Spaggiari, L and Rosell, R
Publicada:
21 may 2015
Categoría:
Medicine (miscellaneous)
Resumen:
Lung cancer is one of the most frequently diagnosed cancers and is the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC), a heterogeneous class of tumours, represents approximately 85% of all new lung cancer diagnoses. Tobacco smoking remains the main risk factor for developing this disease, but radon exposure and air pollution also have a role. Most patients are diagnosed with advanced-stage disease owing to inadequate screening programmes and late onset of clinical symptoms; consequently, patients have a very poor prognosis. Several diagnostic approaches can be used for NSCLC, including X-ray, CT and PET imaging, and histological examination of tumour biopsies. Accurate staging of the cancer is required to determine the optimal management strategy, which includes surgery, radiochemotherapy, immunotherapy and targeted approaches with anti-angiogenic monoclonal antibodies or tyrosine kinase inhibitors if tumours harbour oncogene mutations. Several of these driver mutations have been identified (for example, in epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK)), and therapy continues to advance to tackle acquired resistance problems. Also, palliative care has a central role in patient management and greatly improves quality of life. For an illustrated summary of this Primer, visit: http://go.nature.com/rWYFgg
Filiaciones:
Gridelli, C:
SG Moscati Hosp, Div Med Oncol, I-83100 Avellino, Italy
Rossi, A:
SG Moscati Hosp, Div Med Oncol, I-83100 Avellino, Italy
Carbone, DP:
Ohio State Univ, Med Ctr, James Thorac Ctr, Columbus, OH 43210 USA
Guarize, J:
European Inst Oncol, Dept Thorac Surg, Milan, Italy
Karachaliou, N:
Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Barcelona, Spain
Mok, T:
Chinese Univ Hong Kong, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China
Petrella, F:
European Inst Oncol, Dept Thorac Surg, Milan, Italy
Spaggiari, L:
European Inst Oncol, Dept Thorac Surg, Milan, Italy
:
Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Barcelona, Spain
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