Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure
Por:
Codoner, FM, Pou, C, Thielen, A, Garcia, F, Delgado, R, Dalmau, D, Santos, JR, Buzon, MJ, Martinez-Picado, J, Alvarez-Tejado, M, Clotet, B, Ruiz, L and Paredes, R
Publicada:
1 dic 2010
Resumen:
Using quantitative deep HIV-1 sequencing in a subject who developed virological failure to deep salvage therapy with raltegravir, we found that most Q148R and N155H mutants detected at the time of virological failure originated from pre-existing minority Q148R and N155H variants through independent evolutionary clusters. Double 148R + N155H mutants were also detected in 1.7% of viruses at virological failure in association with E138K and/or G163R. Our findings illustrate the ability of HIV-1 to escape from suboptimal antiretroviral drug pressure through selection of pre-existing drug-resistant mutants, underscoring the importance of using fully active antiretroviral regimens to treat all HIV-1-infected subjects. (C) 2010 Elsevier B.V. All rights reserved.
Filiaciones:
Thielen, A:
Max Planck Inst Informat, Saarbucken, Germany
Garcia, F:
Hosp Univ San Cecilio, Granada, Spain
Delgado, R:
Hosp 12 Octubre, E-28041 Madrid, Spain
Dalmau, D:
Hosp Univ Mutua Terrassa, Terrassa, Spain
:
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
Martinez-Picado, J:
ICREA, Barcelona, Spain
Alvarez-Tejado, M:
Roche Diagnost SL, Sant Cugat Del Valles, Spain
:
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, HIV Unit, IrsiCaixa Retrovirol Lab HIVACAT, Badalona 08916, Catalonia, Spain
Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain
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