Lenalidomide is effective as salvage therapy in refractory or relapsed multiple myeloma: analysis of the Spanish Compassionate Use Registry in advanced patients
Por:
Alegre, A, Aguado, B, Giraldo, P, Rios, E, Canovas, A, Ibanez, A, Castillo, I, Hernandez, MT, Oriol, A, Palomera, L, Rodriguez, JN, Garcia, FL, Calvo, JM, Martinez-Chamorro, C, de la Serna, J and Lahuerta, JJ
Publicada:
1 mar 2011
Categoría:
Hematology
Resumen:
We evaluated the clinical results of lenalidomide (Len) as a compassionate salvage therapy in refractory/relapsed multiple myeloma (MM) patients. A nationwide multi-centre, retrospective research study was performed to evaluate clinical data from patients with advanced MM for which compassionate use of lenalidomide was requested. The primary endpoints were the overall response rate (ORR) and the time to progression (TTP). Secondary objectives included safety and overall survival (OS) since starting of lenalidomide therapy. Data collected from the Spanish Compassionate Use Registry included 111 patients treated in 2006-2008. The median (range) number of previous treatment lines was 3 (1-8). The median duration of lenalidomide treatment while on study was of 4.9 months (1-18). Dexamethasone was given concomitantly with Len in 89% of patients. The ORR was 66% (4% of patients had stringent complete, 11% complete and 11% very good partial responses). Median TTP and OS were 13.0 and 17.4 months, respectively. The depth of response was significantly associated with a longer OS. Toxicity, mainly myelosuppression, was predictable and manageable with Len dose adjustments and cytokine support. Lenalidomide as salvage compassionate therapy in refractory/relapsed MM showed, in this series of heavily pre-treated patients, similar efficacy to that reported in pivotal clinical trials with acceptable tolerance.
Filiaciones:
Alegre, A:
Hosp Univ Princesa, Dept Hematol, Madrid 28006, Spain
Aguado, B:
Hosp Univ Princesa, Dept Hematol, Madrid 28006, Spain
Giraldo, P:
Hosp Miguel Servet, Zaragoza, Spain
Rios, E:
Hosp Virgen Rocio, Seville, Spain
Canovas, A:
Hosp Cruces, Baracaldo, Spain
Ibanez, A:
Complejo Hosp Univ Albacete, Albacete, Spain
Castillo, I:
Hosp Gen Elda, Elda, Spain
Hernandez, MT:
Hosp Univ Canarias, Tenerife, Spain
:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Palomera, L:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Rodriguez, JN:
Hosp Juan Ramon Jimenez, Huelva, Spain
Garcia, FL:
Hosp Univ Princesa, Dept Hematol, Madrid 28006, Spain
Calvo, JM:
Hosp Gen Lanzarote, Gran Canaria, Spain
Martinez-Chamorro, C:
Hosp Univ Quiron, Madrid, Spain
de la Serna, J:
Hosp Univ Doce Octubre, Madrid, Spain
Lahuerta, JJ:
Hosp Univ Doce Octubre, Madrid, Spain
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